DYNLT3 Human

Dynein, Light Chain, Tctex-Type 3 (DYNLT3) is a protein encoded by the DYNLT3 gene in humans. It is a member of a subclass of dynein light chains and plays a crucial role in the cytoplasmic dynein motor protein complex. This complex is responsible for the intracellular retrograde motility of vesicles and organelles along microtubules .

The DYNLT3 gene is located on the X chromosome (chrX:37,838,836-37,847,571) and consists of five exons . The encoded protein is 116 amino acids long and forms a homodimer, which is a part of the larger cytoplasmic dynein 1 complex . This complex includes two catalytic heavy chains and several non-catalytic subunits, including intermediate chains, light intermediate chains, and light chains .

DYNLT3 acts as one of the non-catalytic accessory components of the cytoplasmic dynein 1 complex. It is involved in linking dynein to cargos and adapter proteins that regulate dynein function . The protein is essential for the efficient progression through mitosis and is thought to bind the spindle checkpoint protein BUB3 as part of its transport cargo .

Mutations or dysregulation of the DYNLT3 gene have been associated with various diseases, including breast rhabdomyosarcoma and breast sarcoma . The protein’s role in intracellular transport and mitosis makes it a critical component in cellular function and division.

Human recombinant DYNLT3 is used in various research applications to study its function and role in disease. It is also utilized in experiments to understand the mechanisms of dynein-mediated transport and its interactions with other proteins .