DUSP3 Antibody

Dual Specificity Phosphatase 3, also known as Vaccinia H1-related phosphatase, is a member of the dual specificity protein phosphatase family. These phosphatases are characterized by their ability to dephosphorylate both phosphoserine/threonine and phosphotyrosine residues on their target kinases . This unique capability allows them to play a crucial role in regulating various cellular processes, including cell proliferation, differentiation, and apoptosis.

Dual Specificity Phosphatase 3 is encoded by the DUSP3 gene. The protein is highly conserved across species and is expressed in various tissues, including immune cells . The primary function of Dual Specificity Phosphatase 3 is to inactivate mitogen-activated protein kinases (MAPKs) by dephosphorylating them. This action is essential for controlling the intensity and duration of MAPK signaling pathways, which are involved in numerous cellular responses to external stimuli .

Dual Specificity Phosphatase 3 plays a significant role in the immune system. It is differentially expressed in resting and activated immune cells, where it helps regulate the immune response by modulating MAPK signaling . Studies in knockout mice have shown that the absence of Dual Specificity Phosphatase 3 leads to altered immune responses, highlighting its importance in maintaining immune homeostasis .

Recent research has identified Dual Specificity Phosphatase 3 as a critical regulator of platelet function. It is highly expressed in both human and mouse platelets and is involved in platelet activation and thrombus formation . Inhibition or deficiency of Dual Specificity Phosphatase 3 impairs platelet aggregation and granule secretion, which are essential for thrombus formation. This finding suggests that targeting Dual Specificity Phosphatase 3 could be a potential therapeutic strategy for preventing arterial thrombosis without increasing the risk of bleeding .

Mouse anti Human Dual Specificity Phosphatase 3 antibody is a monoclonal antibody that recognizes and binds to Dual Specificity Phosphatase 3 in human cells . This antibody is commonly used in research to study the expression and function of Dual Specificity Phosphatase 3 in various biological processes. It is also utilized in diagnostic applications to detect abnormalities in Dual Specificity Phosphatase 3 expression, which may be associated with certain diseases .