DSIP
Greater than 97.0% as determined by analysis by RP-HPLC.
Description
DSIP Synthetic is a single, non-glycosylated polypeptide chain containing 15 amino acids, having a molecular mass of 1419.55 Dalton and a Molecular formula of C62H98N16O22.
Product Specs
H-Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val-OH
Product Science Overview
Delta Sleep-Inducing Peptide (DSIP) is a fascinating neuropeptide that has garnered attention for its potential role in sleep regulation and various physiological functions. Discovered in the 1970s, DSIP has been the subject of numerous studies, although its exact mechanisms and applications remain a topic of ongoing research.
DSIP was first isolated from the cerebral blood of rabbits by the Swiss Schoenenberger-Monnier group in 1974 . It is a nonapeptide, meaning it consists of nine amino acids with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu . This peptide is amphiphilic, allowing it to interact with both hydrophilic and hydrophobic environments, which is crucial for its function in the brain and other tissues.
DSIP is primarily known for its ability to induce delta-wave sleep, a deep sleep phase characterized by slow brain waves . It has been found in various parts of the brain, including the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs and body fluids . In the brain, DSIP may interact with NMDA receptors and influence the circadian rhythm .
The exact mechanisms by which DSIP induces sleep are not fully understood. However, it is believed to promote sleep by targeting various areas of the brain and influencing neurotransmitter activity . DSIP is easily absorbed from the gut, crosses the blood-brain barrier, and has a rapid onset of action . It has also been suggested that DSIP may interact with components of the MAPK cascade and is regulated by glucocorticoids .
Despite its initial promise, research on DSIP has been somewhat inconsistent. Some studies have shown that DSIP can induce sleep and regulate circadian rhythms, while others have found conflicting results . DSIP has also been investigated for its potential in treating withdrawal syndromes, hormone optimization, and other physiological benefits .
One of the main challenges in DSIP research is its low molecular stability, with a half-life of only 15 minutes in vitro . This instability has made it difficult to study and develop DSIP-based therapies. However, advances in peptide analogues with greater stability and ongoing research into its mechanisms may pave the way for future applications.
