DPP4 Human, HEK
HEK293 Cells.
Description
DPP4 Human Recombinant is a single, glycosylated polypeptide chain containing 977 amino acids (29-766a.a) and having a molecular mass of 112.1kDa (calculated). DPP4 is fused to a 239 amino acid hIgG-Tag at C-terminus and is purified by proprietary chromatographic techniques.
Product Specs
HEK293 Cells.
DGSMNKGTDD ATADSRKTYT LTDYLKNTYR LKLYSLRWIS DHEYLYKQEN NILVFNAEYG NSSVFLENST FDEFGHSIND YSISPDGQFI LLEYNYVKQW RHSYTASYDI YDLNKRQLIT EERIPNNTQW VTWSPVGHKL AYVWNNDIYV KIEPNLPSYR ITWTGKEDII YNGITDWVYE EEVFSAYSAL WWSPNGTFLA YAQFNDTEVP LIEYSFYSDE SLQYPKTVRV PYPKAGAVNP TVKFFVVNTD SLSSVTNATS IQITAPASML IGDHYLCDVT WATQERISLQ WLRRIQNYSV MDICDYDESS GRWNCLVARQ HIEMSTTGWV GRFRPSEPHF TLDGNSFYKI ISNEEGYRHI CYFQIDKKDC TFITKGTWEV IGIEALTSDY LYYISNEYKG MPGGRNLYKI QLSDYTKVTC LSCELNPERC QYYSVSFSKE AKYYQLRCSG PGLPLYTLHS SVNDKGLRVL EDNSALDKML QNVQMPSKKL DFIILNETKF WYQMILPPHF DKSKKYPLLL DVYAGPCSQK ADTVFRLNWA TYLASTENII VASFDGRGSG YQGDKIMHAI NRRLGTFEVE DQIEAARQFS KMGFVDNKRI AIWGWSYGGY VTSMVLGSGS GVFKCGIAVA PVSRWEYYDS VYTERYMGLP TPEDNLDHYR NSTVMSRAEN FKQVEYLLIH GTADDNVHFQ QSAQISKALV DVGVDFQAMW YTDEDHGIAS STAHQHIYTH MSHFIKQCFS LPKLLEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSRDELTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK.
Product Science Overview
Dipeptidyl-Peptidase 4 (DPP4), also known as CD26, is a serine exopeptidase that plays a crucial role in glucose metabolism, immune regulation, and signal transduction. The recombinant form of this enzyme, expressed in Human Embryonic Kidney (HEK) cells, is widely used in research and therapeutic applications.
DPP4 is a type II transmembrane glycoprotein composed of 766 amino acids . It is characterized by its ability to cleave dipeptides from the N-terminus of polypeptides, specifically those with proline or alanine at the penultimate position . This unique enzymatic activity allows DPP4 to regulate the activity of various bioactive peptides, including incretins, chemokines, and neuropeptides .
The recombinant form of DPP4 is typically produced in HEK 293 cells, which provide a human-like post-translational modification system . The protein is purified to a high degree, often exceeding 95% purity, and is free from endotoxins . This high level of purity is essential for its use in biochemical assays and therapeutic applications.
DPP4 is involved in numerous physiological processes. It acts as a co-stimulatory molecule in T-cell activation, playing a pivotal role in immune responses . Additionally, DPP4 is implicated in the regulation of glucose homeostasis by inactivating incretin hormones, which are responsible for stimulating insulin secretion . This makes DPP4 a target for the treatment of type 2 diabetes, with DPP4 inhibitors being used as therapeutic agents.
