DOK4 Human

DOK4 plays a significant role in various cellular processes. It is involved in RET-mediated neurite outgrowth and has a positive role in the activation of the MAP kinase pathway . The MAP kinase pathway is crucial for various cellular activities, including growth, proliferation, differentiation, and apoptosis.

DOK4 is expressed in various tissues, with the highest expression observed in immune cells . It is primarily localized in the cytosol . The protein’s expression profile across different tissues indicates its involvement in multiple physiological processes.

DOK4 functions as an adaptor protein, meaning it helps in the assembly of signaling complexes without having enzymatic activity itself . This role is crucial in the MAP kinase pathway, where it aids in the transmission of signals from the cell surface to the nucleus, influencing gene expression and cellular responses.

Recombinant DOK4 proteins are used in various research applications to study its function and role in signaling pathways. These proteins are typically expressed in systems like E. coli and purified for use in experiments . They are valuable tools for understanding the molecular mechanisms underlying cellular signaling and for developing potential therapeutic strategies.