DECR1 Antibody
Description
Product Specs
Product Science Overview
2,4-Dienoyl CoA Reductase 1 (DECR1) is an enzyme that plays a crucial role in the beta-oxidation and metabolism of unsaturated fatty acids. This enzyme is encoded by the DECR1 gene, which is located on chromosome 8 in humans . DECR1 is essential for the reduction of 2,4-dienoyl-CoA to trans-3-enoyl-CoA, a critical step in the metabolic pathway of polyunsaturated fatty acids .
DECR1 is an auxiliary enzyme involved in the beta-oxidation of unsaturated fatty enoyl-CoA esters that have double bonds in both even- and odd-numbered positions . It catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA, which is necessary for the continuation of the beta-oxidation process . This enzyme is located in the mitochondrial matrix and is involved in various biological processes, including lipid metabolism and the positive regulation of cold-induced thermogenesis .
The mouse anti-human DECR1 antibody is a monoclonal antibody used in research to study the expression and function of DECR1 in human tissues. This antibody is produced by immunizing mice with human DECR1 protein, and it specifically binds to the DECR1 protein in human cells. The use of mouse anti-human DECR1 antibodies allows researchers to investigate the role of DECR1 in various biological processes and diseases.
The DECR1 gene is highly conserved across different species, including humans and mice . In humans, the gene is located on chromosome 8, while in mice, it is located on chromosome 4 . The protein encoded by the DECR1 gene is a member of the short-chain dehydrogenase/reductase (SDR) family and is involved in the reduction of 2,4-dienoyl-CoA .
DECR1 is involved in the metabolism of unsaturated fatty acids, which are essential components of cell membranes and signaling molecules . The enzyme’s activity is crucial for maintaining cellular energy balance and lipid homeostasis. Mutations or deficiencies in the DECR1 gene can lead to metabolic disorders, such as 2,4-dienoyl-CoA reductase deficiency, which is characterized by the accumulation of unsaturated fatty acids in tissues .
The mouse anti-human DECR1 antibody is widely used in research to study the expression and function of DECR1 in various tissues and cell types. It is used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to detect DECR1 protein levels and localization. This antibody is also used to investigate the role of DECR1 in metabolic diseases and to develop potential therapeutic strategies targeting DECR1.
