DBNDD2 Human

Dysbindin, short for dystrobrevin-binding protein 1, is a protein that plays a crucial role in the dystrophin-associated protein complex (DPC) of skeletal muscle cells. It is also a part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Dysbindin was discovered by Derek Blake’s research group through yeast two-hybrid screening for binding partners of α-dystrobrevin .

Dysbindin is found in neural tissue of the brain, particularly in axon bundles and certain axon terminals, such as mossy fiber synaptic terminals in the cerebellum and hippocampus . It is involved in various cellular processes, including actin cytoskeleton reorganization, regulation of dopamine secretion, and neuron projection morphogenesis .

DBNDD2, or Dysbindin Domain Containing 2, is a protein-coding gene that shares significant homology with dysbindin. It is involved in the negative regulation of protein kinase activity and is predicted to be located in the cytoplasm . Diseases associated with DBNDD2 include Ectodermal Dysplasia 10B and Type 1 Diabetes Mellitus 7 .

Human recombinant dysbindin is produced using recombinant DNA technology, which involves inserting the gene encoding dysbindin into a suitable expression system, such as bacteria or yeast. This allows for the large-scale production of the protein for research and therapeutic purposes.

Dysbindin has been implicated in several neurological and psychiatric disorders, including schizophrenia. Studies have shown that dysbindin is involved in synaptic function and plasticity, and its dysfunction can lead to cognitive deficits and other symptoms associated with these disorders .