CYR61 Human
CYR61, Protein CYR61, Cysteine-rich angiogenic inducer 61, IGF-binding protein 10, IGFBP-10, IBP-10, Protein GIG1, CCN family member 1, CCN1, GIG1, IGFBP10.
Description
The CYR61 is purified by proprietary chromatographic techniques.
Product Specs
This section provides a concise overview of CYR61, highlighting its role as a growth factor-inducible gene with diverse functions in various cancers. It describes CYR61 as a secreted protein that interacts with cells and the extracellular matrix, influencing cell adhesion and growth.
CYR61, Protein CYR61, Cysteine-rich angiogenic inducer 61, IGF-binding protein 10, IGFBP-10, IBP-10, Protein GIG1, CCN family member 1, CCN1, GIG1, IGFBP10.
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Product Science Overview
CYR61 is a secreted protein that interacts with cell surface integrin receptors and heparan sulfate proteoglycans . It regulates a wide range of cellular activities, including:
- Cell adhesion
- Migration
- Proliferation
- Differentiation
- Apoptosis
- Senescence
These interactions are crucial for various physiological processes such as embryonic development, where CYR61 is essential for cardiac septal morphogenesis, blood vessel formation in the placenta, and vascular integrity .
Human recombinant CYR61 is produced using recombinant DNA technology, which involves inserting the CYR61 gene into a suitable expression system to produce the protein in large quantities . This recombinant form is used in research to study its role in angiogenesis and cell adhesion, and it has potential applications in therapeutic interventions for diseases involving abnormal angiogenesis .
The CYR61 gene is located on human chromosome 1p22.3 . The gene spans approximately 3.2 Kb and contains five exons interspaced with four introns . The first exon encodes the 5’-UTR sequence and the initial amino acids in the secretory signal peptide, while the remaining exons encode distinct domains of the CCN1 protein .
