CTNNBIP1 Human
Description
CTNNBIP1 Recombinant E.coli produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (1-81 a.a.) and having a molecular mass of 11.3 kDa. The CTNNBIP1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
MGSSHHHHHH SSGLVPRGSH MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI DQGAEDVVMA FSRSETEDRR Q.
Product Science Overview
CTNNBIP1 is a protein coding gene that produces a protein which binds to beta-catenin (CTNNB1) and prevents its interaction with TCF (T-cell factor) family members . By doing so, it acts as a negative regulator of the Wnt signaling pathway . The Wnt signaling pathway is pivotal in embryonic development and in maintaining the balance between cell proliferation and differentiation in adult tissues .
Mutations or dysregulation of the CTNNBIP1 gene can lead to various diseases. For instance, alterations in this gene have been associated with conditions such as cheilitis and nephrotic syndrome, type 3 . Additionally, the Wnt signaling pathway, which CTNNBIP1 regulates, is often implicated in cancer development, particularly in hepatocellular carcinoma .
Research on CTNNBIP1 has significant implications in understanding and potentially treating diseases related to the Wnt signaling pathway. The recombinant form of this protein is used in various studies to explore its function and interactions. For example, studies have shown that β-catenin, a core effector of the canonical Wnt signaling pathway, plays a pivotal role in controlling lineage commitment and the formation of definitive endoderm during early embryonic development .
