CSNK1D Human
Casein Kinase 1 Delta Human Recombinant
Cat. No.
BT29994
Source
Escherichia Coli.
Synonyms
Casein kinase I isoform delta, CKI-delta, CKId, Tau-protein kinase CSNK1D, CSNK1D, HCKID, delta isoform 2, Casein Kinase 1 Delta, Casein kinase 1.
Appearance
CSNK1D is supplied as a sterile filtered clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
CSNK1D Human Recombinant produced in E. coli is a single polypeptide chain containing 429 amino acids (1-409) and having a molecular mass of 48.9kDa.
CSNK1D is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CSNK1D is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Introduction
Casein kinase I gene family members are involved in regulating cytoplasmic and nuclear processes, including DNA replication and repair. Casein Kinase 1 Delta (CSNK1D), a member of this family, is a crucial serine/threonine-protein kinase. It plays a vital role in various cellular growth and survival processes, such as Wnt signaling and circadian rhythms. CSNK1D is responsible for phosphorylating numerous proteins.
Description
Recombinant human CSNK1D, produced in E. coli, is a single polypeptide chain consisting of 429 amino acids (residues 1-409). It has a molecular weight of 48.9kDa. The protein includes a 20 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic methods.
Physical Appearance
CSNK1D is provided as a clear, sterile solution that has been filtered.
Formulation
The CSNK1D solution has a concentration of 1mg/ml and contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, and 0.4M Urea.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For longer periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for extended storage. Avoid repeated freezing and thawing.
Purity
Purity is greater than 85.0% as determined by SDS-PAGE analysis.
Synonyms
Casein kinase I isoform delta, CKI-delta, CKId, Tau-protein kinase CSNK1D, CSNK1D, HCKID, delta isoform 2, Casein Kinase 1 Delta, Casein kinase 1.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MELRVGNRYR LGRKIGSGSF GDIYLGTDIA AGEEVAIKLE CVKTKHPQLH IESKIYKMMQ GGVGIPTIRW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGASRA ADDAERERRD REERLRHSRN PATRGLPSTA SGRLRGTQEV APPTPLTPTS HTANTSPRPV SGMERERKVS MRLHRGAPVN ISSSDLTGRQ DTSRMSTSQN SIPFEHHGK.
Product Science Overview
Structure and Isoforms
CK1δ is one of several isoforms within the CK1 family, which also includes CK1α, CK1γ1, CK1γ2, CK1γ3, and CK1ε . These isoforms share a high degree of homology in their catalytic domains but differ in their N-terminal and C-terminal non-catalytic domains . The molecular weight of CK1 isoforms ranges from 37 kD (CK1α) to 51 kD (CK1γ3) .
Biological Functions
CK1δ is involved in multiple cellular functions:
- Cell Proliferation and DNA Damage Response: CK1δ regulates cell proliferation and is involved in the DNA damage response .
- Circadian Rhythm: CK1δ plays a significant role in the regulation of circadian rhythms by phosphorylating key proteins involved in the circadian clock .
- Tumorigenesis: CK1δ has been implicated in cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog . It is genetically amplified in a portion of human epithelial ovarian cancer (EOC) .
Mechanisms of Action
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