CSDC2 Human

Cold Shock Domain Containing C2 (CSDC2) is a protein encoded by the CSDC2 gene in humans. This protein is part of the cold shock domain (CSD) family, which is characterized by the presence of one or more cold shock domains. These domains are known for their nucleic acid binding properties, which enable them to participate in various cellular processes, including the regulation of transcription, translation, and splicing .

The CSDC2 gene is located on chromosome 22 and is a protein-coding gene. The protein encoded by this gene contains a cold shock domain, which is crucial for its function in nucleic acid binding. The CSDC2 protein is also known by other names, such as RNA-Binding Protein PIPPin .

CSDC2 is an RNA-binding factor that specifically binds to the very 3’-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. This binding activity suggests that CSDC2 might play a central role in the negative regulation of histone variant synthesis in the developing brain . Additionally, CSDC2 is predicted to be involved in the regulation of mRNA stability and is active in both the nucleus and cytoplasm .

Cold shock proteins, including CSDC2, are among the most evolutionarily conserved proteins. They are found in almost all organisms, from bacteria to humans, except yeast. This conservation highlights their fundamental role in cellular processes .

The expression patterns of cold shock proteins, including CSDC2, have been linked to various diseases, including cancer and inflammatory diseases. The ability of these proteins to regulate the expression of disease-associated genes makes them potential targets for therapeutic interventions .

With the advent of recombinant DNA technology, the expression and production of recombinant proteins, including CSDC2, have become feasible and cost-effective. Recombinant CSDC2 can be produced in various host organisms, providing a valuable tool for research and potential therapeutic applications .