CSAG1 Human

Chondrosarcoma Associated Gene 1 Human Recombinant

Cat. No.

BT2761

Source

Escherichia Coli.

Synonyms

Chondrosarcoma Associated Gene 1, CSAG1, Cancer/Testis Antigen 24.1, Cancer/Testis Antigen CSAGE, CSAGE, CT24.1, Cancer/Testis Antigen Family 24, Member 1, Cancer/Testis Antigen Family 24 Member 1, Putative Chondrosarcoma-Associated Gene 1 Protein.

Appearance

Sterile Filtered clear solution.

Purity

Greater than 90.0% as determined by SDS-PAGE.

Usage

Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

CSAG1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 82 amino acids (20-78) and having a molecular mass of 9.1 kDa.
CSAG1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

CSAG1 (Chondrosarcoma Associated Gene 1) is a tumor antigen found in chondrosarcomas. It may also be present in healthy tissues like the testis.

Description

Recombinant human CSAG1, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 82 amino acids (20-78). It has a molecular weight of 9.1 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.

Physical Appearance

Clear, sterile-filtered solution.

Formulation

The CSAG1 solution (0.25 mg/ml) is supplied in a buffer containing 20 mM Tris-HCl (pH 8.0), 0.15 M NaCl, 10% glycerol, and 1 mM DTT.

Stability

For short-term storage (2-4 weeks), keep at 4°C. For longer periods, store frozen at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.

Purity

Purity is greater than 90.0% as determined by SDS-PAGE.

Synonyms

Source

Escherichia Coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSDQVDWSR LYRDTGLVKM SRKPRASSPF SNNHPSTPKR FPRQPKREKG PVKEVPGTKG SP.

Product Science Overview

Expression and Function

CSAG1 is highly expressed in chondrosarcomas, a type of cancer that forms in cartilage cells, as well as in other cancers and certain normal tissues like the testis and brain. The protein encoded by this gene may play a crucial role in maintaining the integrity of the centrosome during mitosis, which is essential for proper cell division .

Alternative Splicing

The CSAG1 gene undergoes alternative splicing, resulting in two transcript variants that encode the same protein. This process allows for the generation of multiple protein isoforms from a single gene, contributing to the complexity of gene regulation and protein function.

Clinical Significance

The expression of CSAG1 in chondrosarcomas and other cancers makes it a potential biomarker for these diseases. Biomarkers are molecules that can be used to detect or monitor a disease, and they are crucial for accurate diagnosis and treatment planning. In the case of chondrosarcoma, which is a cartilage-forming malignancy, accurate diagnostic markers are essential due to the tumor’s resistance to chemotherapy and radiotherapy.

Research and Therapeutic Potential

Research into CSAG1 and its role in cancer biology is ongoing. Understanding the function and regulation of this gene could lead to the development of new diagnostic tools and therapeutic strategies for chondrosarcoma and other cancers. For instance, targeting the pathways involved in centrosome integrity during mitosis could provide new avenues for cancer treatment.

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CSAG1 Human

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