CRABP2 Antibody
Description
Product Specs
Product Science Overview
Cellular Retinoic Acid Binding Protein 2 (CRABP2) is a member of the retinoic acid (RA) binding protein family, which plays a crucial role in the retinoid signaling pathway. This protein is involved in the transport of retinoic acid to the nucleus, where it regulates the access of retinoic acid to its nuclear receptors .
CRABP2 is a cytosol-to-nuclear shuttling protein that facilitates the binding of retinoic acid to its cognate receptor complex and its transfer to the nucleus . The protein is composed of 138 amino acids and has a high affinity for all-trans-retinoic acid, the most active metabolite of vitamin A . Upon ligand binding, CRABP2 undergoes a conformational change that exposes a nuclear localization motif, allowing the protein to be transported into the nucleus .
CRABP2 is involved in various biological processes, including embryonic development, epidermis development, and the regulation of DNA-templated transcription . It plays a significant role in the retinoic acid metabolic process and signal transduction . The protein is also associated with increased circulating low-density lipoprotein cholesterol .
Mutations or alterations in the expression of CRABP2 have been linked to several diseases, including embryonal carcinoma and keratoacanthoma . The protein’s role in retinoid signaling makes it a potential target for therapeutic interventions in conditions related to vitamin A deficiency and retinoic acid metabolism .
Mouse anti-human CRABP2 antibodies are commonly used in research to study the expression and function of CRABP2 in various biological contexts. These antibodies are valuable tools for immunohistochemistry, western blotting, and other immunoassays to detect CRABP2 in human tissues and cells.
