CRABP1 Antibody
Description
Product Specs
Product Science Overview
Cellular Retinoic Acid Binding Protein 1 (CRABP1) is a highly conserved cytosolic protein that plays a crucial role in the regulation of retinoic acid (RA) signaling. RA, the active metabolite of vitamin A, is essential for various physiological processes, including development, differentiation, and homeostasis. CRABP1 is known for its high binding affinity for RA, which allows it to modulate the intracellular availability and activity of RA.
CRABP1 is structurally similar to cellular retinol-binding proteins but is specific to retinoic acid. It binds RA with high affinity and is involved in the sequestration and channeling of RA to specific cellular compartments. This protein is essential for the non-canonical signaling pathways of RA, which are independent of the nuclear RA receptors (RARs). These non-canonical pathways include the activation of kinases such as MAPK and CaMKII, which are involved in various cellular processes .
CRABP1 has been implicated in several cellular processes, including differentiation, proliferation, and apoptosis. It is particularly important in the context of stem cells and cancer cells, where it modulates cell cycle progression and apoptosis through its interaction with RA. In stem cells, CRABP1-mediated RA signaling can slow down proliferation and promote differentiation .
Mouse anti-human CRABP1 antibodies are commonly used in research to study the expression and function of CRABP1 in various human tissues. These antibodies are generated by immunizing mice with human CRABP1 protein, leading to the production of specific antibodies that can bind to human CRABP1. These antibodies are valuable tools for immunohistochemistry, Western blotting, and other immunoassays to investigate the role of CRABP1 in human health and disease.
Research on CRABP1 has revealed its involvement in several physiological and pathological conditions. For instance, CRABP1 has been shown to modulate stem cell proliferation and differentiation, which has implications for regenerative medicine and cancer therapy. Additionally, alterations in CRABP1 expression and function have been linked to neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), where CRABP1 protects against neuronal stress and death .
