COX5A Antibody
Description
Product Specs
Product Science Overview
Cytochrome c oxidase subunit Va (COX Va) is a critical component of the mitochondrial respiratory chain, specifically involved in the electron transport chain. This subunit is part of the larger cytochrome c oxidase complex (Complex IV), which plays a pivotal role in cellular respiration by facilitating the transfer of electrons from cytochrome c to molecular oxygen, ultimately contributing to the generation of ATP through oxidative phosphorylation.
COX Va is essential for the proper functioning of the cytochrome c oxidase complex. It is involved in maintaining the structural integrity and catalytic activity of the enzyme. The subunit is encoded by nuclear DNA and is imported into the mitochondria, where it integrates into the inner mitochondrial membrane. The proper assembly and function of COX Va are crucial for efficient energy production in cells.
Research has shown that COX Va is implicated in various diseases, particularly those related to mitochondrial dysfunction. For instance, alterations in COX Va expression have been associated with neurodegenerative diseases such as Alzheimer’s disease. Studies have demonstrated that COX Va plays a role in memory impairment associated with brain aging via the BDNF/ERK1/2 signaling pathway . Additionally, COX Va has been identified as a potential biomarker for the aggressiveness of non-small cell lung cancer (NSCLC), with its expression correlating with migration, invasion, and metastasis of cancer cells .
The mouse anti-human COX Va antibody is a monoclonal antibody specifically designed to target the human COX Va protein. This antibody is widely used in research to study the expression and function of COX Va in various biological contexts. It is particularly useful in techniques such as western blotting, immunohistochemistry, and immunofluorescence, allowing researchers to visualize and quantify COX Va in tissue samples and cell lines.
- Cancer Research: The mouse anti-human COX Va antibody is used to investigate the role of COX Va in cancer progression, particularly in identifying its expression in tumor tissues and understanding its involvement in cancer cell metabolism and metastasis.
- Neurodegenerative Diseases: Researchers utilize this antibody to study the changes in COX Va expression in neurodegenerative diseases, aiming to elucidate its role in mitochondrial dysfunction and neuronal degeneration.
- Mitochondrial Studies: The antibody is also employed in studies focusing on mitochondrial biology, helping to explore the mechanisms of mitochondrial respiration and the impact of COX Va on cellular energy production.
