Collagen-III Bovine
Bovine washed dissected tissue.
Filtered White lyophilized (freeze-dried) powder.
> 90.0%.
Description
Mouse Collagen-III is a natural protein purified from washed dissected tissue into dilute acetic acid. Collagen-I is purified by proprietary chromatographic techniques.
Product Specs
Collagen is a fibrous protein crucial for tissue strength and structural integrity within the extracellular matrix. Collagen and its derivative, gelatin, have widespread applications in medical, pharmaceutical, and consumer products. While animal-derived sources are abundant and cost-effective, they carry potential risks of inflammatory reactions, disease transmission (e.g., mad cow disease), and batch-to-batch variability due to natural modifications. Recombinant collagens, being nearly identical to native forms, offer a safer and more consistent alternative, minimizing inflammation, immune responses, and disease risks.
Mouse Collagen-III is obtained through a purification process involving the washing and extraction of dissected tissue with dilute acetic acid. Subsequent purification of Collagen-I is achieved using proprietary chromatographic methods.
White lyophilized powder (freeze-dried).
Collagen-III undergoes lyophilization without the addition of additives.
To prepare a working stock solution (1-5 mg/ml), it is recommended to reconstitute the lyophilized powder in 20 mM acetic acid. This solution can be further diluted with aqueous solutions as needed. Ensure thorough mixing (shaking or stirring) for several hours or overnight at a temperature between 2-8°C.
Lyophilized Collagen-III remains stable at room temperature for up to three weeks; however, it is recommended to store it desiccated at temperatures below -18°C for optimal preservation. Once reconstituted, Collagen-III should be stored at 4°C for a maximum of 2-7 days. For long-term storage, freezing below -18°C is recommended. Consider adding a carrier protein (0.1% HSA or BSA) for enhanced stability during storage. Avoid repeated freeze-thaw cycles to maintain product integrity.
Greater than 90.0%.
Bovine washed dissected tissue.
Product Science Overview
Bovine Collagen-III is derived from cows and is one of the primary sources of collagen used in supplements and medical applications. It is composed of trimers of identical alpha 1 (III) chains, which are linked to each other by interchain disulfide bonds . These trimers are also cross-linked via hydroxylysines, enhancing the stability and functionality of the collagen fibers .
Bovine collagen is typically extracted from cow bones, connective tissues, cartilage, or hides. The extraction process involves boiling these materials in water to release the collagen, which is then dried and powdered to form a supplement . This process ensures that the collagen retains its bioactive properties, making it suitable for various applications.
There are over 20 types of collagen in the human body, each serving a specific function. The main types are I, II, III, and IV . Bovine collagen is rich in types I and III, which are essential for skin, bone, and joint health . Type III collagen, in particular, supports the structure of muscles, organs, and arteries, promoting overall youthful vitality .
- Skin Health: Type III collagen is a major component of the extracellular matrix in the skin’s dermis. It helps maintain skin elasticity and hydration, reducing the appearance of wrinkles .
- Joint and Bone Health: Collagen-III supports the structure of bones and joints, reducing the risk of degenerative conditions such as osteoarthritis .
- Muscle and Organ Support: This type of collagen is crucial for the structural integrity of muscles and organs, ensuring their proper function .
- Wound Healing: Collagen-III plays a significant role in wound healing by promoting the formation of new tissue and blood vessels .
