CNBP Antibody

Cellular Nucleic Acid Binding Protein (CNBP), also known as zinc finger protein 9, is a highly conserved protein that plays a crucial role in various biological processes. It is known for its involvement in transcription regulation, cell proliferation, and apoptosis during vertebrate organogenesis . CNBP is characterized by its seven tandem cysteine-cysteine-histidine-cysteine (CCHC) zinc-knuckle repeats and a glycine/arginine-rich region, which is similar to the arginine-glycine-glycine (RGG) box of RNA-binding proteins .

CNBP acts as a nucleic acid chaperone, regulating the transcription of several genes, including c-myc, wnt, and skeletal muscle chloride channel 1 (clc1) . It also inhibits the translation of ribosomal protein mRNAs (rp-mRNAs) . CNBP has been implicated in various human diseases, such as myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) .

CNBP is a key transcriptional regulator required for activating the innate immune response. It binds to specific motifs in the promoter region of inflammatory cytokines, directly inducing the expression of target genes . For example, lipopolysaccharide (LPS) induces CNBP expression through an NF-κB-dependent manner, enabling prolonged interleukin-6 (IL-6) gene expression . This process is crucial for maintaining the immune response, as demonstrated by the increased susceptibility of CNBP-depleted zebrafish to Shigella flexneri infection .

The mouse anti-human CNBP antibody is a monoclonal antibody used in various research applications to study the function and regulation of CNBP in human cells. This antibody is designed to specifically bind to human CNBP, allowing researchers to investigate its role in different cellular processes and disease states.

The mouse anti-human CNBP antibody is widely used in immunohistochemistry, Western blotting, and immunoprecipitation assays to detect and quantify CNBP in human tissues and cell lines. It is also employed in studies exploring the molecular mechanisms underlying CNBP-mediated transcription regulation, immune response, and disease pathogenesis.