CKS2 Human

CDC28 Protein Kinase 2, also known as CKS2 (CDC28 Protein Kinase Regulatory Subunit 2), is a protein coding gene that plays a crucial role in cell cycle regulation. It is a part of the human CKS family, which is essential for early embryonic development, somatic cell division, and meiosis .

CKS2 binds to the catalytic subunit of cyclin-dependent kinases (CDKs) and is essential for their biological function . CDKs are a family of protein kinases that regulate the cell cycle, transcription, mRNA processing, and differentiation of nerve cells. The CKS2 protein is involved in the regulation of the cell cycle, particularly in the transition from the G1 phase to the S phase and the G2 phase to the M phase .

The expression of CKS2 is tightly regulated and varies throughout the cell cycle. In HeLa cells, CKS2 mRNA is found to be expressed in different patterns, reflecting its specialized role in cell cycle regulation . The upregulation of CKS2 has been observed in various cancer types, including lower grade gliomas (LGGs), where it is associated with poor prognosis .

CKS2 has been identified as a prognostic biomarker in lower grade gliomas. Studies have shown that increased expression of CKS2 is associated with poor survival rates in LGG patients . The protein’s involvement in cell cycle regulation makes it a potential target for cancer therapy, as disrupting its function could inhibit the proliferation of cancer cells.

Research on CKS2 has provided insights into its role in cancer and other diseases. The protein’s interaction with CDKs and its regulation of the cell cycle make it a valuable target for drug development. Recombinant CKS2 protein is used in various biochemical assays to study its function and interactions with other proteins.