CITED2 Human
Description
The CITED2 is fused to an 8 amino acid His Tag at C-terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The CITED2 gene is located on chromosome 6q24.1 and consists of three exons separated by two small introns . The gene encodes a protein that is 213 amino acids long and contains three histidine clusters and two conserved domains: the 14-amino acid CR1 (conserved region 1) and the acidic 49-amino acid CR2 . The CR2 domain includes 12 aspartic acid and glutamic acid residues that are strictly conserved among human and mouse MRG1 and MSG1 proteins .
CITED2 functions as a transcriptional coactivator of the p300/CBP-mediated transcription complex . It acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex to stimulate TFAP2-mediated transcriptional activation . Additionally, CITED2 positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex . It also enhances estrogen-dependent transactivation mediated by estrogen receptors and stimulates the transcriptional activity of peroxisome proliferator-activated receptors (PPARA) .
Mutations in the CITED2 gene are associated with cardiac septal defects, including atrial septal defect 8 and ventricular septal defect 2 . The protein encoded by this gene inhibits the transactivation of HIF1A-induced genes by competing with the binding of hypoxia-inducible factor 1-alpha to p300-CH1 .
CITED2 Human Recombinant is produced in E. coli as a single, non-glycosylated polypeptide chain containing 278 amino acids (1-270 a.a.) and has a molecular mass of 29.5 kDa . The recombinant protein is fused to an 8 amino acid His Tag at the C-terminus and purified using proprietary chromatographic techniques .
