CIAO1 Antibody
Description
Product Specs
Product Science Overview
Cytosolic Iron-Sulfur Protein Assembly 1 (CIA1) is a crucial component of the cytosolic iron-sulfur (Fe-S) protein assembly machinery in eukaryotic cells. This machinery is responsible for the insertion of Fe-S clusters into cytosolic and nuclear proteins, which are essential for various cellular processes, including respiration, DNA repair, and ribosome biogenesis .
Iron-sulfur clusters are inorganic cofactors composed of iron and sulfur atoms. They play a vital role in electron transfer reactions and enzyme catalysis. The biogenesis of Fe-S clusters is a highly coordinated process that involves multiple cellular compartments, primarily the mitochondria and the cytosol .
The CIA machinery is responsible for the maturation of Fe-S proteins in the cytosol and nucleus. This process involves several key steps:
CIA1 is a central component of the CIA machinery. It forms part of the CIA-targeting complex (CTC), which is responsible for recognizing and binding to client proteins that require Fe-S clusters. The CTC ensures the correct delivery of Fe-S clusters to these target proteins, facilitating their proper function .
The mouse anti-human CIA1 antibody is a monoclonal antibody developed to specifically recognize and bind to the human CIA1 protein. This antibody is used in various research applications, including:
Understanding the function and regulation of CIA1 is critical for elucidating the mechanisms of Fe-S protein maturation. Defects in the CIA machinery can lead to various diseases, including mitochondrial disorders and cancer. Therefore, research on CIA1 and its role in Fe-S cluster biogenesis has significant implications for human health and disease .
