CGREF1 Human
Description
Product Specs
The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage.
Repeated freezing and thawing should be avoided.
Product Science Overview
CGREF1 is a secreted protein that contains two highly conserved calcium-binding EF-hand domains . These EF-hand domains are essential for the protein’s function, which includes binding calcium ions and facilitating cell-cell adhesion . The protein is predicted to inhibit cell growth in various cell lines, making it a significant player in the negative regulation of cell population proliferation .
The CGREF1 gene is located on human chromosome 2 and encodes a 301-amino acid protein . The protein shares a high degree of sequence identity with its orthologs in other species, such as mice and rats . The gene is also known by several aliases, including CGR11 and Cell Growth Regulatory Gene 11 Protein .
CGREF1 is involved in several critical biological processes. It is induced by the tumor suppressor protein p53 and can inhibit cell growth in various cell lines . This makes it a potential target for cancer research and therapy. Additionally, CGREF1 is most likely digested extracellularly by an unknown serine protease, generating highly hydrophobic bioactive peptides .
Recombinant forms of CGREF1, such as the human recombinant protein, are used in various research applications. These include studying the protein’s role in cell growth regulation, calcium ion binding, and cell-cell adhesion . The recombinant protein is typically expressed in systems like E. coli and purified for use in experiments .
