CEBPB Antibody
Description
Product Specs
Product Science Overview
CCAAT/enhancer-binding protein beta (C/EBPβ) is a transcription factor that plays a crucial role in regulating gene expression involved in various cellular processes, including differentiation, proliferation, and inflammation. This protein is part of the CCAAT/enhancer-binding protein (C/EBP) family, which consists of six members: C/EBPα, C/EBPβ, C/EBPγ, C/EBPδ, C/EBPε, and C/EBPζ .
C/EBPβ is characterized by a highly conserved basic-leucine zipper (bZIP) domain at the C-terminus, which is essential for dimerization and DNA binding. This domain allows C/EBPβ to form homodimers or heterodimers with other C/EBP family members or other transcription factors . The protein also contains activation domains at the N-terminus and regulatory domains that are involved in transcriptional activation and repression .
C/EBPβ interacts with the CCAAT box motif present in the promoters of various genes, promoting their expression. It is involved in several cellular responses, including the control of cellular proliferation, growth, differentiation, metabolism, and immunity . C/EBPβ is expressed in various tissues, including the liver, adipose tissue, brain, and hematopoietic cells .
C/EBPβ was initially identified as a regulator of differentiation and inflammatory processes in adipose tissue and liver. However, its function in the brain was largely unknown for many years . Recent studies have shown that C/EBPβ is implicated in inflammatory processes and brain injury. For instance, mice lacking the C/EBPβ gene were found to be less susceptible to kainic acid-induced brain injury .
One of the significant findings is that C/EBPβ directly regulates the expression of the complement component 3 (C3) gene in neural cells. C3 is a central component of the complement system and is implicated in various brain disorders . The regulation of C3 by C/EBPβ suggests that C/EBPβ may mediate pro-inflammatory effects in neural cells .
Mouse anti-human C/EBPβ antibodies are monoclonal antibodies developed to specifically recognize and bind to the human C/EBPβ protein. These antibodies are widely used in research to study the expression, localization, and function of C/EBPβ in various biological contexts. They are also used in immunohistochemistry, Western blotting, and other immunoassays to detect C/EBPβ in human tissues and cells.
