CDKN2AIPNL Human

CDKN2A Interacting Protein N-Terminal Like Human Recombinant
Cat. No.
BT29945
Source
Escherichia Coli.
Synonyms
CDKN2AIP N-terminal-like protein, CDKN2A-interacting protein N-terminal-like protein, CDKN2AIPNL.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs
In Stock
Quick Inquiry

Description

CDKN2AIPNL Human Recombinant produced in E. coli is. a single polypeptide chain containing 139 amino acids (1-116) and having a molecular mass of 15.6kDa. CDKN2AIPNL is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
CDKN2A Interacting Protein N-Terminal Like, also known as CDKN2AIPNL, belongs to the CARF family of proteins.
Description
Recombinant human CDKN2AIPNL, expressed in E. coli, is a single polypeptide chain with a molecular weight of 15.6 kDa. It consists of 139 amino acids, including amino acids 1-116 of the CDKN2AIPNL protein, and a 23 amino acid His-tag fused to its N-terminus. Purification is achieved using proprietary chromatographic techniques.
Physical Appearance
The product is a clear solution that has been sterilized by filtration.
Formulation
The CDKN2AIPNL protein is supplied in a solution at a concentration of 0.25 mg/ml. The solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol, and 1mM DTT.
Stability
For optimal storage, the product should be kept at 4°C if it will be used within 2-4 weeks. For long-term storage, it is recommended to store the product frozen at -20°C. To ensure stability during long-term storage, the addition of a carrier protein (0.1% HSA or BSA) is recommended. Repeated freezing and thawing of the product should be avoided.
Purity
The purity of CDKN2AIPNL, as assessed by SDS-PAGE analysis, is greater than 85%.
Synonyms
CDKN2AIP N-terminal-like protein, CDKN2A-interacting protein N-terminal-like protein, CDKN2AIPNL.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMVGGEAA AAVEELVSGV RQAADFAEQF RSYSESEKQW KARMEFILRH LPDYRDPPDG SGRLDQLLSL SMVWANHLFL GCSYNKDLLD KVMEMADGIE VEDLPQFTTR SELMKKHQS.

Product Science Overview

Gene and Protein Information
  • Gene Symbol: CDKN2AIPNL
  • Aliases: CDKN2AIP N-Terminal-Like Protein, MGC13017
  • UniProtKB/Swiss-Prot ID: Q96HQ2
  • NCBI Gene ID: 91368
  • HGNC ID: 30545

The CDKN2AIPNL gene is located on chromosome 5 and encodes a protein that is predicted to be active in the nucleolus and nucleoplasm . The human recombinant form of this protein is produced in E. coli and consists of a single polypeptide chain containing 139 amino acids, with a molecular mass of approximately 15.6 kDa .

Biological Function

CDKN2AIPNL is involved in the regulation of the cell cycle, particularly through its interaction with the CDKN2A gene. The CDKN2A gene encodes several transcript variants that function as inhibitors of CDK4 kinase, a crucial regulator of cell cycle G1 progression . By interacting with CDKN2A, CDKN2AIPNL may play a role in stabilizing the tumor suppressor protein p53, which is essential for preventing uncontrolled cell proliferation and tumor development .

Expression and Localization

CDKN2AIPNL is expressed in various tissues, with its activity predominantly observed in the nucleolus and nucleoplasm . This localization suggests that the protein may be involved in processes such as ribosome biogenesis and the regulation of gene expression at the transcriptional level.

Clinical Significance

Given its interaction with the CDKN2A gene, CDKN2AIPNL is of interest in cancer research. The CDKN2A gene is frequently mutated or deleted in a wide variety of tumors, making it a critical target for understanding cancer development and progression . The study of CDKN2AIPNL and its recombinant forms could provide valuable insights into the mechanisms of tumor suppression and potential therapeutic strategies.

Recombinant Protein Production

The human recombinant form of CDKN2AIPNL is produced using E. coli expression systems. The recombinant protein includes a 23 amino acid His-tag at the N-terminus, which facilitates its purification through chromatographic techniques . This recombinant protein is used in various research applications to study its function and interactions in a controlled environment.

Quick Inquiry

Personal Email Detected
Please use an institutional or corporate email address for inquiries. Personal email accounts ( such as Gmail, Yahoo, and Outlook) are not accepted. *

Category

Service

THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
  • Contact
  • Address: 1925 E Maple Ave, El Segundo, CA 90245 United States
  • Phone : +1 201-285-7826
  • Email : info@thebiotek.com
  • Hours : Mon.-Fri. 9:00 AM - 5:00 PM
© Copyright 2024 Thebiotek. All Rights Reserved.