CCDC104 Human

Coiled-Coil Domain Containing 104 (CCDC104) is a protein that belongs to the family of coiled-coil domain-containing proteins. These proteins are characterized by the presence of one or more alpha-helical peptides that wrap around each other in a superhelical fashion, forming a coiled-coil structure . Coiled-coil domains are widespread and play crucial roles in various biological processes, including structural support, signal transduction, and molecular transport .

The coiled-coil domain is a highly conserved structural motif found in approximately 10% of an organism’s proteome . It consists of two or more alpha-helices that are wound around each other to form a stable, supercoiled bundle. This structure is stabilized by hydrophobic interactions between the helices, as well as by specific amino acid sequences that promote the coiling .

CCDC104, like other coiled-coil domain-containing proteins, is involved in a variety of cellular functions. These include:

• Structural Support: Coiled-coil domains provide rigidity and stability to the protein structures they are part of. This is essential for maintaining the integrity of cellular components such as the cytoskeleton .
• Signal Transduction: Coiled-coil domains play a role in the transmission of signals within the cell. They are often found in proteins involved in signaling pathways, where they facilitate the interaction between different signaling molecules .
• Molecular Transport: Coiled-coil domains are involved in the transport of molecules within the cell. They can form channels or pores that allow the passage of ions and other small molecules .

The recombinant form of CCDC104, produced through genetic engineering techniques, has several applications in biotechnology and research. Recombinant proteins are produced by inserting the gene encoding the protein into a host organism, such as bacteria or yeast, which then expresses the protein. This allows for the production of large quantities of the protein for research and industrial purposes.

Some of the applications of recombinant CCDC104 include:

• Structural Studies: Recombinant CCDC104 can be used to study the structure and function of coiled-coil domains. This can provide insights into the mechanisms by which these domains contribute to protein function and stability .
• Drug Development: Understanding the role of coiled-coil domains in disease processes can aid in the development of new therapeutic agents. Recombinant CCDC104 can be used in screening assays to identify compounds that target coiled-coil domains .
• Biomaterials: Coiled-coil domains have been used to design self-assembling protein nanostructures. Recombinant CCDC104 can be utilized in the development of novel biomaterials with specific structural and functional properties .