CARD17 Human

Caspase Recruitment Domain Family, Member 17 (CARD17), also known as Inhibitory CARD (INCA), is a protein that plays a crucial role in the regulation of inflammation and apoptosis. It is part of the larger Caspase Recruitment Domain (CARD) family, which is involved in various cellular processes, including immune responses and cell death.

CARD17 is characterized by the presence of a CARD domain, which is a type of protein interaction module belonging to the death domain superfamily. This superfamily includes other domains such as the death effector domain and the pyrin domain. The CARD domain is typically involved in the regulation of apoptosis and inflammation by mediating protein-protein interactions.

CARD17 functions as a regulator of procaspase-1 (CASP1) activation. It is implicated in the regulation of the proteolytic maturation of pro-IL-1beta (IL1B) and its release during inflammation. Specifically, CARD17 inhibits the release of IL1B in response to lipopolysaccharide (LPS) in monocytes .

The CARD domain facilitates the formation of protein complexes that are essential for the activation of caspases, which are proteases involved in the execution phase of apoptosis. CARD17, however, does not induce NF-kappa-B activation, which is a pathway commonly associated with inflammation .

CARD17 is associated with several diseases, including benign renovascular hypertension and benign secondary hypertension . Its role in regulating inflammation makes it a potential target for therapeutic interventions in inflammatory diseases.

Recombinant CARD17 proteins are used in various research applications to study their role in inflammation and apoptosis. These proteins are produced using recombinant DNA technology, which allows for the expression of human CARD17 in various host systems. This enables researchers to investigate the protein’s function and interactions in a controlled environment .