CAMK4 Human
Description
CAMK4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Calcium/Calmodulin-Dependent Protein Kinase IV (CaMKIV) is a multifunctional enzyme that belongs to the serine/threonine protein kinase family. It plays a critical role in various cellular processes, including inflammatory response, T cell maturation, dendritic cell survival, memory consolidation, regulation of the cell cycle, apoptosis, and the development of neurons and male germ cells .
CaMKIV is activated by the binding of calcium ions (Ca²⁺) to calmodulin (CaM), a calcium-binding messenger protein. This binding induces conformational changes in CaM, which then activates CaMKIV. The activation of CaMKIV is part of the calcium-triggered CaMKK-CaMKIV signaling cascade . This cascade is regulated mainly by phosphorylation and controls the activity of several transcription factors, such as CREB1, MEF2D, JUN, and RORA .
CaMKIV is involved in various biological functions:
- Inflammatory Response: It plays a role in the regulation of immune responses and inflammation.
- T Cell Maturation: CaMKIV is essential for the maturation of T cells, which are crucial for the adaptive immune system.
- Memory Consolidation: It is involved in the processes that stabilize a memory trace after its initial acquisition.
- Cell Cycle Regulation and Apoptosis: CaMKIV regulates the cell cycle and apoptosis, ensuring proper cell division and programmed cell death.
- Neuronal and Germ Cell Development: It is critical for the development of neurons and male germ cells .
Overexpression and increased activity of CaMKIV have been linked to various types of cancer, including hepatocellular carcinoma, breast cancer, neuroblastoma, prostate cancer, and acute myeloid leukemia (AML). Additionally, CaMKIV is associated with several syndromes such as azoospermia, cerebral hypoxia, and systemic lupus .
