CALB2 Antibody
Description
Product Specs
Product Science Overview
Calbindin-2 contains six EF-hand motifs, which are helix-loop-helix structures capable of binding calcium ions. These motifs enable Calbindin-2 to bind multiple calcium ions, thereby regulating intracellular calcium concentrations. This regulation is essential for various cellular processes, including neurotransmitter release, muscle contraction, and gene expression .
Calbindin-2 is expressed in a variety of tissues, with the highest levels found in the brain. Within the brain, it is localized to specific neuronal populations, where it plays a role in modulating neuronal excitability and protecting neurons from calcium-mediated excitotoxicity. In addition to the central nervous system, Calbindin-2 is also found in other tissues, such as the retina, adrenal gland, and certain endocrine cells .
Calbindin-2 has been implicated in several neurological disorders. Altered expression of Calbindin-2 has been observed in conditions such as Alzheimer’s disease, epilepsy, and schizophrenia. Its role in buffering intracellular calcium levels makes it a potential target for therapeutic interventions aimed at modulating calcium signaling in these disorders .
The Mouse Anti Human Calbindin-2 Antibody is a monoclonal antibody that specifically binds to human Calbindin-2. This antibody is widely used in research to study the expression and localization of Calbindin-2 in various tissues. It is commonly employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence .
- Western Blotting: The Mouse Anti Human Calbindin-2 Antibody is used to detect Calbindin-2 protein levels in tissue extracts. This technique helps researchers understand the expression patterns of Calbindin-2 in different tissues and under various experimental conditions.
- Immunohistochemistry: This antibody is used to visualize the localization of Calbindin-2 in tissue sections. It allows researchers to study the distribution of Calbindin-2 in specific cell types and brain regions.
- Immunofluorescence: The antibody is also used in immunofluorescence assays to detect Calbindin-2 in cultured cells or tissue sections. This technique provides high-resolution images of Calbindin-2 localization within cells.
