C8G Human
Description
The C8G is fused to a 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Complement Component 8 (C8) is a crucial part of the complement system, which is an essential component of the innate immune system. The complement system enhances the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen’s cell membrane. C8 is composed of three subunits: alpha (C8α), beta (C8β), and gamma (C8γ). The gamma subunit, also known as Complement Component 8, Gamma (C8G), is one of the three subunits that constitute C8 .
The C8G subunit belongs to the lipocalin family and is one of the three subunits that make up the C8 protein. C8 is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain . The gamma subunit is not required for the bactericidal activity of C8 but plays a role in the formation of the membrane attack complex (MAC) on bacterial cell membranes .
Recent studies have revealed an inhibitory role of C8G in neuroinflammation. In patients with Alzheimer’s disease, who exhibit strong neuroinflammation, higher levels of C8G have been found in brain tissue, cerebrospinal fluid (CSF), and plasma . Experiments using recombinant C8G protein and shRNA-mediated knockdown showed that C8G inhibits glial hyperactivation, neuroinflammation, and cognitive decline in acute and chronic animal models of Alzheimer’s disease . Additionally, C8G interacts with sphingosine-1-phosphate receptor 2 (S1PR2) to antagonize the pro-inflammatory action of sphingosine-1-phosphate (S1P) in microglia .
