C7ORF49 Human

Chromosome 7 Open Reading Frame 49 Human Recombinant
Cat. No.
BT9955
Source
E.coli.
Synonyms
MRI, Modulator of retrovirus infection homolog, C7orf49.
Appearance
Sterile Filtered colorless solution.
Purity
Greater than 85% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

C7ORF49 Human Recombinant produced in E. coli is a single polypeptide chain containing 180 amino acids (1-157) and having a molecular mass of 19.2kDa. C7ORF49 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
Belonging to the lncRNA class, Chromosome 7 Open Reading Frame 49 (C7ORF49) is believed to play a role in viral infection response. Studies on the hamster equivalent of C7ORF49 indicate it might influence how effectively the proteasome, a cellular structure, breaks down viral cores following infection.
Description
C7ORF49 Human Recombinant protein, produced in E. coli, is a single polypeptide chain comprising 180 amino acids. This includes the 157 amino acids of C7ORF49 itself and a 23 amino acid His-tag attached to its N-terminus. With a molecular weight of 19.2kDa, it undergoes purification using proprietary chromatographic methods.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The C7ORF49 solution is provided at a concentration of 0.25mg/ml in a buffer consisting of 20mM Tris-HCl (pH 8.0), 10% glycerol, and 0.1M NaCl.
Stability
For short-term storage (2-4 weeks), the product can be stored at 4°C. For extended storage, freezing at -20°C is recommended. Adding a carrier protein like 0.1% HSA or BSA is advisable for long-term storage. Repeated freezing and thawing should be avoided.
Purity
SDS-PAGE analysis indicates a purity exceeding 85%.
Synonyms
MRI, Modulator of retrovirus infection homolog, C7orf49.
Source
E.coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMETLQSE TKTRVLPSWL TAQVATKNVA PMKAPKRMRM AAVPVAAARL PATRTVYCMN EAEIVDVALG ILIESRKQEK ACEQPALAGA DNPEHSPPCS VSPHTSSGSS SEEEDSGKQA LAPGLSPSQR PGGSSSACSR SPEEEEEEDV LKYVREIFFS.

Product Science Overview

Gene and Protein Information
  • Gene Symbol: C7ORF49
  • Chromosomal Location: Chromosome 7
  • Protein Class: Long non-coding RNA (lncRNA)
Function and Significance

The exact function of C7ORF49 is not fully understood, but it is believed to play a role in modulating the ability of the proteasome to degrade retroviral cores upon cellular infection . This suggests that C7ORF49 may have a role in the cellular response to viral infections, potentially influencing the degradation of viral components and affecting the overall viral lifecycle.

Research and Applications

Recombinant forms of C7ORF49 are used in various research applications to study its function and potential role in disease processes. These recombinant proteins are produced using human cells to ensure they closely mimic the natural protein’s structure and function. They are valuable tools for:

  • Studying Protein Interactions: Understanding how C7ORF49 interacts with other proteins and cellular components.
  • Investigating Viral Infections: Exploring the role of C7ORF49 in the cellular response to viral infections.
  • Potential Therapeutic Targets: Identifying how modulation of C7ORF49 activity could be used in therapeutic interventions.
Availability

Recombinant Human Chromosome 7 Open Reading Frame 49 proteins are available from various suppliers for research purposes . These proteins are typically provided in purified forms and can be used in a range of experimental setups.

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THE BIOTEK
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