C6 Human
Human Plasma.
Complement component C6, C6.
Sterile filtered solution.
Greater than 90.0% as determined by SDS-PAGE.
Description
Human Complement C6 produced in Human plasma having a molecular mass of 105 kDa.
Product Specs
This paragraph details the role of C6 in the complement system, highlighting its activation by C5b and its importance in forming the membrane attack complex (MAC) for cell membrane disruption. It explains the activation process of C6 and the formation of the C5b,6,7 complex, essential for MAC assembly and target cell membrane insertion.
This describes the origin and molecular weight of the Human Complement C6 protein offered: It's derived from human plasma and has a molecular mass of 105 kDa.
This specifies the physical state of the product as a sterilized solution, free from particulate matter.
This describes the solution in which the C6 protein is provided. It is dissolved in a phosphate buffer saline solution with a neutral pH of 7.2.
This section provides guidelines for storing the C6 Human product to maintain its stability. For short-term use (2-4 weeks), refrigeration at 4°C is sufficient. Long-term storage requires freezing below -20°C, ideally with a carrier protein like HSA or BSA to preserve protein integrity. Repeated freezing and thawing should be avoided to prevent protein degradation.
This states that the purity of the Human Complement C6 is greater than 90%, confirmed by SDS-PAGE analysis, a standard method for determining protein purity.
This confirms that the plasma used in the production of this C6 protein has been tested and confirmed negative for common bloodborne viruses, including HIV-1, HIV-2, Hepatitis C (HCV), and Hepatitis B surface antigen (HBsAg).
Complement component C6, C6.
Human Plasma.
Product Science Overview
C6 is a glycosylated protein composed of a single polypeptide chain with a molecular weight of approximately 105,000 Da . It is an essential component of the membrane attack complex (MAC), which is formed during the terminal phase of the complement activation pathway . The MAC is responsible for creating pores in the plasma membrane of target cells, leading to cell lysis and death .
The formation of the MAC involves several steps:
The primary function of C6 is to participate in the formation of the MAC, which is crucial for the immune system’s ability to destroy pathogens. The MAC can target a wide range of pathogens, including bacteria, viruses, and other foreign cells . This process is vital for the body’s defense against infections and maintaining overall health.
Deficiency in C6 can lead to increased susceptibility to bacterial infections, particularly those caused by Neisseria species . Individuals with C6 deficiency may experience recurrent infections and may require medical interventions to manage their condition. Genetic mutations in the C6 gene are responsible for this deficiency, and various transcript variants encoding the same protein have been described .
Research on C6 and the complement system has significant implications for understanding immune responses and developing therapeutic interventions. Studies have explored the genetic associations of C6 with various diseases and conditions, including its role in the host response to vaccines and its involvement in cancer . Additionally, the study of C6 and the complement system has led to the development of targeted therapies for immune-related disorders.
