C1QBP Antibody

Complement Component 1, Mouse Anti Human
Cat. No.
BT13297
Source
Synonyms
p32, HABP1, gC1Qr, GC1QBP, SF2p32, gC1Q-R, Complement component 1 Q subcomponent-binding protein mitochondrial, Glycoprotein gC1qBP, C1qBP, GC1q-R protein, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, p33, C1QBP.
Appearance
Sterile filtered colorless solution.
Purity
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Product Specs

Introduction
C1QBP, also known as gC1qR or p32, is a multifunctional protein involved in various cellular processes. It binds to the globular heads of complement component C1q, inhibiting the classical complement pathway activation. C1QBP interacts with a diverse range of ligands, including hyaluronic acid, and participates in cell signaling pathways. As a component of the pre-mRNA splicing factor SF2, it plays a role in RNA splicing. C1QBP has been implicated in tumor development, serving as a marker for tumor cells and tumor-associated macrophages in hypoxic regions. It has also been shown to mediate apoptosis induced by the tumor suppressor protein p14ARF. Furthermore, C1QBP exhibits chemotactic properties for immature dendritic cells through its interaction with C1q and C1q receptors. In viral infections, C1QBP can interfere with viral replication by blocking mRNA accumulation and modulating RNA polymerase II activity. Additionally, it has been shown to interact with the Hepacivirus core protein, potentially affecting T cell signaling.
Physical Appearance
A clear and colorless solution that has been sterilized by filtration.
Formulation
The antibody is supplied in a solution containing 1mg/ml of antibody in a buffer consisting of PBS at pH 7.4, 10% glycerol, and 0.02% sodium azide.
Storage Procedures
For short-term storage of up to one month, keep the antibody at a temperature of 4°C. For prolonged storage, it is recommended to store the antibody at -20°C. Repeated freezing and thawing of the antibody should be avoided to maintain its stability.
Stability / Shelf Life
The antibody remains stable for a period of 12 months when stored at a temperature of -20°C. At a temperature of 4°C, the antibody can be stored for up to 1 month.
Applications
This C1QBP antibody has undergone testing using ELISA and Western blot analysis to confirm its specificity and reactivity. However, as the specific application can vary, it is essential to optimize the antibody concentration for each experiment to achieve the best results.
Synonyms
p32, HABP1, gC1Qr, GC1QBP, SF2p32, gC1Q-R, Complement component 1 Q subcomponent-binding protein mitochondrial, Glycoprotein gC1qBP, C1qBP, GC1q-R protein, Hyaluronan-binding protein 1, Mitochondrial matrix protein p32, p33, C1QBP.
Purification Method
C1QBP antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Type
Mouse Anti Human Monoclonal.
Clone
PAT1G7AT.
Immunogen
Anti-human C1QBP mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human C1QBP protein 74-282 amino acids purified from E. coli.
Ig Subclass
Mouse IgG1 heavy chain and k light chain.

Product Science Overview

Introduction

Complement Component 1 (C1) is a crucial part of the classical pathway of the complement system, which is an essential component of the innate immune response. The complement system consists of a series of proteins that work together to identify and eliminate pathogens, as well as to clear damaged cells and promote inflammation.

Structure and Function

C1 is a complex protein composed of three subcomponents: C1q, C1r, and C1s. C1q is the recognition molecule that binds to the Fc region of antibodies (IgG or IgM) that are attached to antigens on the surface of pathogens. This binding activates C1r and C1s, which are serine proteases. The activation of C1r and C1s leads to the cleavage of C4 and C2, ultimately forming the C3 convertase, which is a key enzyme in the complement cascade .

Mouse Anti-Human C1 Antibodies

Mouse anti-human C1 antibodies are monoclonal antibodies produced in mice that specifically target human C1 components. These antibodies are used in research and diagnostic applications to study the role of C1 in various diseases and to develop potential therapeutic interventions.

Applications in Research

Mouse anti-human C1 antibodies are valuable tools in immunology research. They are used to:

  1. Investigate the role of C1 in autoimmune diseases: C1q deficiency is associated with autoimmune diseases such as systemic lupus erythematosus (SLE). Studies using mouse models have shown that C1q plays a protective role against autoimmunity .
  2. Study the involvement of C1 in neurodegenerative diseases: C1q has been implicated in the process of synapse pruning during development and in neurodegenerative diseases .
  3. Explore the therapeutic potential of C1 inhibition: Inhibiting C1 activity has been proposed as a potential therapeutic strategy for diseases where excessive complement activation contributes to pathology .

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Complement Component 1 Human Recombinant
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THE BIOTEK
THE BioTek is a global biotech company offering highly purified proteins for research in cancer, apoptosis, development, endocrinology, immunology, neuroscience, proteases, and stem cells.
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