Buserelin
Buserelin
Cat. No.
BT15763
Source
Synonyms
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Shipped with Ice Packs 
In Stock 
Description
Buserelin contains 9 amino acids Glu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt and having a molecular weight of 1239.44 Dalton.
Product Specs
Introduction
Buserelin is a gonadotrophin-releasing hormone (GnRH) analog, specifically an LHRH agonist. It acts on the pituitary gland, which regulates the production of various hormones. Buserelin alters hormone levels, particularly estrogen and androgen levels. This hormone manipulation is used to treat prostate cancer, as testosterone stimulates the growth of prostate tumors. Buserelin reduces testosterone levels, depriving the tumor of this hormone and causing it to shrink.
Description
Buserelin is a peptide composed of 9 amino acids: Glu-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt. It has a molecular weight of 1239.44 Daltons.
Physical Appearance
Sterile, white, lyophilized (freeze-dried) powder.
Formulation
The Buserelin peptide is lyophilized without any additives.
Solubility
Reconstitute the lyophilized Buserelin in sterile 18MΩ-cm H2O at a concentration of at least 100 µg/ml. This solution can be further diluted in other aqueous solutions.
Stability
Lyophilized Buserelin remains stable at room temperature for up to 3 weeks but should be stored desiccated below -18°C. After reconstitution, store Buserelin at 4°C for 2-7 days. For future use, store below -18°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid freeze-thaw cycles.
Purity
Purity exceeds 98.0% as determined by:
(a) Reverse-phase high-performance liquid chromatography (RP-HPLC) analysis.
(b) Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis.
Product Science Overview
Chemical Structure and Properties
Buserelin has the chemical formula C60H86N16O13 and a molar mass of approximately 1,239.47 g/mol . It is a GnRH agonist, meaning it stimulates the GnRH receptors in the pituitary gland, leading to an initial surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels, followed by a downregulation of these hormones with continued use .
Mechanism of Action
Buserelin works by initially stimulating the release of LH and FSH from the pituitary gland. However, with prolonged administration, it desensitizes the GnRH receptors, leading to a decrease in the production of sex hormones such as testosterone and estrogen . This reduction in hormone levels is beneficial in treating hormone-sensitive conditions.
Clinical Uses
- Prostate Cancer: Buserelin is used to reduce testosterone levels, which can help slow the growth of hormone-sensitive prostate cancer .
- Endometriosis: By lowering estrogen levels, buserelin helps alleviate the symptoms of endometriosis, a condition where tissue similar to the lining inside the uterus grows outside it .
- Precocious Puberty: Buserelin is used to delay early onset puberty by reducing the levels of sex hormones .
- Assisted Reproduction: It is also used in fertility treatments to control hormone levels before ovulation induction .
Administration and Dosage
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