Borrelia Miyamotoi GlpQ

Borrelia Miyamotoi GlpQ Recombinant
Cat. No.
BT29171
Source
Escherichia Coli.
Synonyms
Appearance
Sterile Filtered clear solution.
Purity
Greater than 80.0% as determined by SDS-PAGE.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

Recombinant Borrelia Miyamotoi GlpQ produced in E.coli is a non-glycosylated, polypeptide chain having a calculated molecular mass of 38,132 Dalton.
Borrelia Miyamotoi GlpQ is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.

Product Specs

Introduction
Borrelia is a genus of bacteria within the spirochete phylum known for causing borreliosis. This zoonotic, vector-borne disease is primarily transmitted through tick bites, with some species relying on lice. Among the 36 identified Borrelia species, 12 are linked to Lyme disease or borreliosis, spread via ticks. The most common species causing Lyme disease are Borrelia burgdorferi, Borrelia afzelii, and Borrelia garinii. Members of the Borrelia genus possess a linear chromosome approximately 900 kbp long and a significant number of linear and circular plasmids ranging from 5 to 220 kbp in size. These plasmids are unique compared to typical bacterial plasmids due to their high content of paralogous sequences, pseudogenes, and in certain instances, essential genes. Furthermore, some plasmids exhibit characteristics suggestive of prophages.
Description
Recombinant Borrelia Miyamotoi GlpQ, produced in E.coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 38,132 Daltons. This protein is expressed with a 10xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Physical Appearance
A clear solution that has been sterile filtered.
Formulation
Borrelia Miyamotoi GlpQ is provided in a buffer solution of 20mM HEPES at pH 7.6, containing 250mM NaCl and 20% glycerol.
Stability
For short-term storage (2-4 weeks), the product can be kept at 4°C. For extended storage, freeze the product at -20°C. Minimize repeated freeze-thaw cycles.
Purity
Purity exceeds 80.0% as determined by SDS-PAGE analysis.
Source
Escherichia Coli.

Product Science Overview

Introduction to Borrelia Miyamotoi

Borrelia miyamotoi is a tick-borne spirochete that belongs to the relapsing fever group of Borrelia species. It was first discovered in 1994 in Japan within the midguts of Ixodes persulcatus ticks . Unlike other relapsing fever Borrelia, which are typically transmitted by soft ticks, B. miyamotoi is transmitted by hard-bodied ticks, the same species that transmit Lyme disease . This pathogen has been identified as a human pathogen causing hard tick-borne relapsing fever (HTBRF) across the Northern Hemisphere .

GlpQ Protein

The GlpQ protein is a glycerophosphodiester phosphodiesterase that plays a crucial role in the metabolism of glycerophosphodiesters. In Borrelia species, GlpQ is an important antigen used for serodiagnosis. The GlpQ protein of B. miyamotoi is particularly significant because it is used in serological assays to detect infections . However, current serodiagnostic tests based on GlpQ have limitations in sensitivity, especially during the acute phase of the infection .

Recombinant GlpQ Protein

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