BMPR1B Human

Bone Morphogenetic protein Receptor-1B Human Recombinant

Cat. No.

BT17531

Source

Escherichia Coli.

Synonyms

Bone Morphogenetic Protein Receptor, Type IB, BMP Type-1B Receptor, EC 2.7.11.30, BMPR-1B, ALK6, Bone Morphogenetic Protein Receptor Type-1B, Serine/Threonine Receptor Kinase, CDw293 Antigen, EC 2.7.11, CDw293, ALK-6, Bone morphogenetic protein receptor type-1B.

Appearance

Sterile Filtered colorless solution.

Purity

Greater than 80.0% as determined by SDS-PAGE.

Usage

THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

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Description

BMPR1B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 136 amino acids (14-126 a.a) and having a molecular mass of 15.1kDa.

BMPR1B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction

Bone Morphogenetic protein Receptor-1B, also known as BMPR1B, is a member of the TKL Ser/Thr protein kinase family. Upon ligand binding, BMPR1B forms a receptor complex composed of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors, which then autophosphorylate. These activated type I receptors subsequently bind and activate SMAD transcriptional regulators. BMPR1B acts as a receptor for both BMP7/OP-1 and GDF5.

Description

Recombinant human BMPR1B, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 136 amino acids (residues 14-126) with a molecular weight of 15.1 kDa. This protein includes a 23 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic methods.

Physical Appearance

A clear, colorless, and sterile-filtered solution.

Formulation

The BMPR1B protein solution is provided at a concentration of 0.5 mg/ml and is formulated in a buffer containing phosphate buffered saline (pH 7.4), 20% glycerol, 1 mM DTT, and 0.1 mM PMSF.

Stability

For short-term storage (2-4 weeks), the product should be stored at 4°C. For extended storage, freezing at -20°C is recommended. To ensure optimal stability during long-term storage, the addition of a carrier protein (0.1% HSA or BSA) is advised. It is important to avoid repeated freeze-thaw cycles.

Purity

The purity of the BMPR1B protein is greater than 80.0% as determined by SDS-PAGE analysis.

Synonyms

Source

Escherichia Coli.

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD GPIHHR.

Product Science Overview

Introduction

Bone Morphogenetic Protein Receptor-1B (BMPR1B) is a member of the bone morphogenetic protein (BMP) receptor family, which belongs to the larger transforming growth factor-beta (TGF-β) superfamily. These receptors are transmembrane serine/threonine kinases that play crucial roles in various biological processes, including embryogenesis, tissue homeostasis, and disease progression .

Structure and Function

BMPR1B is a type I receptor that forms heteromeric complexes with type II receptors to transduce BMP signals. The receptor complex typically consists of two type I and two type II receptors. Type II receptors bind BMP ligands in the absence of type I receptors, but signaling requires the presence of both receptor types. Upon ligand binding, BMPR1B undergoes phosphorylation, which activates downstream signaling pathways, including the SMAD pathway, leading to the regulation of gene expression.

Biological Roles

BMPR1B is involved in several critical biological processes:

Endochondral Bone Formation: BMPR1B plays a pivotal role in the formation of bones through endochondral ossification, a process where cartilage is replaced by bone.
Embryogenesis: During embryonic development, BMPR1B is essential for the proper formation of various tissues and organs.
Tissue Homeostasis: BMPR1B helps maintain the balance and function of tissues in the adult organism.

Clinical Significance

Mutations in the BMPR1B gene have been associated with several diseases:

Primary Pulmonary Hypertension: Mutations in BMPR1B can lead to primary pulmonary hypertension, a condition characterized by high blood pressure in the lungs.
Acromesomelic Dysplasia: This genetic disorder, which affects bone growth, has also been linked to mutations in BMPR1B.
Brachydactyly Type A1: A condition characterized by shortened fingers and toes, caused by mutations in BMPR1B.

Recombinant BMPR1B

Human recombinant BMPR1B is produced using recombinant DNA technology, which involves inserting the BMPR1B gene into a suitable expression system, such as bacteria or mammalian cells, to produce the protein in large quantities. This recombinant protein is used in various research and therapeutic applications to study BMP signaling pathways and to develop treatments for diseases associated with BMPR1B dysfunction.

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BMPR1B Human

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