BMP 5 Human
Description
BMP-5 is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Bone Morphogenetic Protein-5 (BMP-5) is a member of the bone morphogenetic protein family, which is part of the transforming growth factor-beta (TGF-β) superfamily. BMPs are known for their ability to induce bone and cartilage development. BMP-5, in particular, plays a crucial role in tissue development, repair, and regeneration .
BMPs were initially identified by their ability to induce endochondral osteogenesis in vivo in an extraskeletal site. This discovery was made by Professor Marshall Urist and Professor Hari Reddi . BMP-5 is an essential signaling molecule within the trabecular meshwork and optic nerve head, and it may play a potential role in glaucoma pathogenesis .
BMP-5 is a protein encoded by the BMP5 gene in humans. The human recombinant form of BMP-5 is produced in Escherichia coli (E. coli) and is a single, non-glycosylated polypeptide chain containing 139 amino acids, with a total molecular mass of 15.7 kDa . The protein is purified using proprietary chromatographic techniques to ensure high purity and stability .
Recombinant human BMPs (rhBMPs) are used in various orthopedic applications, such as spinal fusions, nonunions, and oral surgery. BMP-5 has been shown to increase the levels of osteopontin, BMP-2, alkaline phosphatase, and core binding factor alpha 1 mRNAs in human periodontal ligament cells . This makes it a promising candidate for tissue engineering and regenerative medicine.
The BMP-5 human recombinant protein is formulated in a sterile, filtered colorless solution containing 10mM Sodium Citrate buffer (pH 3.5) and 10% Glycerol. It is recommended to store the protein at 4°C if it will be used within 2-4 weeks, or frozen at -20°C for longer periods. For long-term storage, adding a carrier protein (0.1% HSA or BSA) is advised to avoid multiple freeze-thaw cycles .
