BETV6.0102
Allergenic isoflavone reductase-like protein Bet v 6.0102, BETV6.0102.
Description
Recombinant BETV6.0102 produced in SF9 is a glycosylated, polypeptide chain having a calculated molecular mass of 36,636 Dalton.
BETV6.0102 is expressed with a 10xHis tag at N-terminus and purified by proprietary chromatographic techniques.
Product Specs
Allergenic isoflavone reductase-like protein Bet v 6.0102, BETV6.0102.
Product Science Overview
The Allergenic Isoflavone Reductase-Like Protein Bet v 6.0102 is a recombinant protein derived from the birch tree pollen, specifically from the species Betula pendula and Betula verrucosa. This protein is a minor allergen known to cause allergic reactions in individuals sensitized to birch pollen. It is part of the larger Bet v 6 family of allergens, which includes various isoforms and variants.
Bet v 6.0102 functions as an isoflavone reductase, an enzyme involved in the reduction of isoflavones. Isoflavones are a class of flavonoids found in various plants, and they play a role in plant defense mechanisms. The enzyme activity of Bet v 6.0102 contributes to the plant’s ability to respond to environmental stressors and pathogens.
Bet v 6.0102 is recognized as an allergen due to its ability to bind to Immunoglobulin E (IgE) antibodies in sensitized individuals. Approximately 10-15% of individuals sensitized to birch pollen exhibit IgE reactivity to Bet v 6 . This allergen can cause a range of allergic symptoms, including skin reactions, respiratory allergies (such as asthma), gastrointestinal reactions, conjunctivitis, and oral allergy syndrome (swelling and itching of the tongue, lips, and throat).
Bet v 6.0102 shares amino acid sequence similarity with other isoflavone reductases from various plants, leading to cross-reactivity with proteins from different plant-based foods and other tree or grass pollens. Common cross-reactive foods include apples, carrots, bananas, pears, peaches, nectarines, peanuts, walnuts, celery, and tomatoes . This cross-reactivity can result in allergic reactions when individuals consume these foods.
The prevalence of Bet v 6 sensitivity varies across different geographical regions. In northern and central European countries, birch pollen is a significant source of aeroallergen-mediated allergic reactions. Studies have shown that the percentage of birch-allergic patients ranges from 6.8% to 57.4%, with the highest prevalence in Denmark and the lowest in Portugal . In a study conducted in Germany, Bet v 6 had a prevalence of 10-15% among the allergic population .
Recombinant Bet v 6.0102 is produced using biotechnological methods to obtain a pure and consistent form of the protein. This recombinant protein is used in various research and diagnostic applications to study the allergenic properties of Bet v 6 and to develop diagnostic tests for birch pollen allergies .
