The DLX gene family consists of at least six members: DLX1 to DLX6. These genes are homologous to the Drosophila Distal-less (Dll) gene, which is involved in the development of the head and limbs in fruit flies. The DLX proteins contain a homeobox domain, a conserved sequence that allows them to bind to DNA and regulate the expression of other genes .
BP-1 is expressed in various tissues during embryonic development, particularly in the brain and craniofacial regions. It is believed to play a role in the differentiation and proliferation of cells in these areas. The protein’s function is essential for proper development, and mutations or dysregulation of DLX genes can lead to developmental disorders .
Recombinant BP-1 is produced using various expression systems, including E. coli and wheat germ. The protein is often tagged with GST (Glutathione S-transferase) at the N-terminal to facilitate purification and detection. The recombinant protein typically corresponds to specific amino acid sequences of the full-length human DLX4 protein .
Recombinant BP-1 is used in various research applications, including: