BAIAP2 Human
Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI1-associated protein 2, Protein BAP2, Fas ligand-associated factor 3, FLAF3, IRS-58, IRSp53/58, IRSP53.
Description
BAIAP2 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Product Specs
Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI1-associated protein 2, Protein BAP2, Fas ligand-associated factor 3, FLAF3, IRS-58, IRSp53/58, IRSP53.
Product Science Overview
BAIAP2 is a substrate for the insulin receptor tyrosine kinase and binds to the small GTPase Rac . It plays a crucial role in the regulation of the actin cytoskeleton, which is essential for various cellular functions such as cell shape, motility, and division. The protein is known to interact with other proteins involved in cytoskeletal dynamics, thereby influencing cell morphology and movement.
The BAI1-Associated Protein 2 is significant in the context of brain-specific angiogenesis inhibitors (BAIs). BAIs, including BAI1, BAI2, and BAI3, are members of the adhesion G protein-coupled receptors (GPCRs) family, which share a conserved seven-transmembrane structure and an N-terminal extracellular domain . These proteins are involved in the regulation of angiogenesis, synaptogenesis, and tumor development .
Recent studies have highlighted the emerging roles of the BAI1 protein family in various biological processes, including phagocytosis, synaptogenesis, neurovasculature, and tumor development . The ability of BAIAP2 to regulate certain signaling pathways makes it a potential target for therapeutic interventions in diseases such as cancer, stroke, and schizophrenia .
