BABAM1 Human
Description
BABAM1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
BABAM1 is a component of two significant multi-subunit deubiquitination complexes: BRCA1-A and BRISC . These complexes are involved in different cellular functions:
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BRCA1-A Complex: This complex is specifically recruited to DNA repair foci, where it recognizes ‘Lys-63’-linked ubiquitinated histones H2A and H2AX at DNA lesion sites. The BRCA1-A complex targets the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). It also possesses deubiquitinase activity that removes ‘Lys-63’-linked ubiquitin on histones H2A and H2AX, thereby playing a critical role in DNA repair .
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BRISC Complex: The BRISC complex, which includes the metabolic enzyme SHMT2, regulates various biological processes such as the immune response, mitosis, and hematopoiesis. It also plays a role in the deubiquitination of specific substrates, thereby modulating their stability and function .
The K63-linked ubiquitination is a fundamental mechanism underlying cellular signaling. Ubiquitin molecules can form chains through isopeptide bonds between lysine residues, and these chains differ structurally depending on the linkage type. K63-linked ubiquitination is essential for DNA repair, stress response, immune response, and membrane protein homeostasis .
Mutations or dysregulation of BABAM1 can lead to various diseases. For instance, it has been associated with conditions such as Cherubism and Deafness, Autosomal Recessive 53 . Additionally, knockdown studies of NBA1 (another alias for BABAM1) have shown increased sensitivity of cells to DNA damage caused by ionizing radiation, ultraviolet radiation, and chemical DNA-damaging agents .
Research on BABAM1 has provided insights into its role in DNA repair and ubiquitin signaling. Understanding the function of BABAM1 and its associated complexes can lead to the development of therapeutic strategies for diseases related to DNA damage and repair mechanisms. The recombinant form of this protein is used in various experimental setups to study its function and interactions in a controlled environment.
