Axin1 Antibody

Axin-1, also known as Axis inhibition protein 1, is a crucial scaffold protein involved in the regulation of the WNT signaling pathway. This pathway is essential for various developmental processes, including embryonic axis formation. Axin-1 contains several important domains, such as the regulation of G-protein signaling (RGS) domain and the disheveled and axin (DIX) domain .

Axin-1 plays a pivotal role as a negative regulator of the WNT signaling pathway. It interacts with key proteins such as adenomatosis polyposis coli (APC), beta-catenin, and glycogen synthase kinase 3 beta (GSK-3β) to form a tetrameric complex. This complex is responsible for the regulation of beta-catenin stabilization, which is crucial for controlling cell proliferation and differentiation .

Mutations in the AXIN1 gene have been associated with various carcinomas, indicating its role as a tumor suppressor. The disruption of Axin-1 function can lead to uncontrolled cell growth and cancer development .

Mouse anti-human Axin-1 antibodies are monoclonal antibodies derived from hybridization of mouse myeloma cells with spleen cells from immunized mice. These antibodies are highly specific to human Axin-1 and are used in various scientific applications, including immunohistochemistry, immunocytochemistry, Western blot, ELISA, and immunoprecipitation .

The mouse anti-human Axin-1 antibody is a valuable tool in research for studying the WNT signaling pathway and its implications in cancer and developmental biology. It helps in detecting and quantifying Axin-1 protein levels in different biological samples, providing insights into the molecular mechanisms underlying various diseases .