Atosiban
Atosiban
Cat. No.
BT15672
Source
Synonyms
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity
Greater than 98.0% as determined by analysis by RP-HPLC.
Usage
THE BioTek's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description
Atosiban also called ADH (Anti-Diuretic Hormone) has a molecular formula of C43H67N11O12S2, 3-Mercaptopropionyl-D-Tyr(ET)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 having a Mw of 994.2 Dalton.
Product Specs
Introduction
Atosiban is the first oxytocin antagonist specifically developed to treat preterm labor. It works by blocking oxytocin receptors in the uterus, inhibiting oxytocin-induced uterine contractions. Extensive clinical studies have demonstrated that Atosiban is at least as effective as existing tocolytic medications. Furthermore, because of its unique and targeted mechanism of action, Atosiban has a significantly better maternal side effect profile than traditional treatments.
Description
Atosiban, also known as Anti-Diuretic Hormone (ADH), has a molecular formula of C₄₃H₆₇N₁₁O₁₂S₂ and a molecular weight of 994.2 Daltons. Its chemical structure is 3-Mercaptopropionyl-D-Tyr(ET)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH₂.
Physical Appearance
White, sterile-filtered lyophilized (freeze-dried) powder.
Formulation
The Atosiban peptide is lyophilized without any additional ingredients.
Solubility
Reconstitute the lyophilized Atosiban in sterile 18MΩ-cm H2O at a concentration of at least 100 µg/ml. This solution can then be further diluted in other aqueous solutions.
Stability
While lyophilized Atosiban remains stable at room temperature for up to 3 weeks, it is recommended to store it desiccated below -18°C. After reconstitution, store Atosiban at 4°C for 2-7 days. For long-term storage, freeze at -18°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
The purity of this product is greater than 98.0% as determined by RP-HPLC analysis.
Product Science Overview
Development and Approval
Chemical Structure
Mechanism of Action
Atosiban works by inhibiting the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. This inhibition reduces the release of intracellular calcium from the sarcoplasmic reticulum and decreases the influx of calcium from the extracellular space through voltage-gated channels . As a result, it suppresses uterine contractions, thereby delaying preterm labor.
Medical Uses
Administration
Side Effects
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