ASNA1 Antibody
Description
Product Specs
Product Science Overview
The arsA arsenite transporter ATP-binding homolog 1 is a protein that plays a crucial role in the resistance to arsenicals. This protein is encoded by the ASNA1 gene in humans and is homologous to the bacterial arsA gene. The protein is also known by several other names, including ARSA-I, ARSA1, ASNA-I, GET3, TRC40, and hASNA-I .
The ASNA1 gene is located on chromosome 19 in humans and on chromosome 8 in mice . The gene encodes a protein that is part of a multisubunit oxyanion pump responsible for the transport of arsenite and antimonite ions across cell membranes . The protein has ATPase activity, meaning it can hydrolyze ATP to provide the energy required for the transport process .
In Escherichia coli, the arsA ATPase is the catalytic component of the arsenite transporter system, which provides resistance to arsenicals and antimonials . The human homolog, ASNA1, performs a similar function by acting as an arsenite-stimulated ATPase component of the arsenite transporter . This protein is also involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER) . It recognizes and selectively binds the transmembrane domain (TMD) of TA proteins in the cytosol and delivers them to the ER for insertion .
The arsA arsenite transporter ATP-binding homolog 1 is essential for cellular resistance to toxic arsenic compounds. By transporting arsenite out of the cell, it helps to mitigate the toxic effects of arsenic exposure . Additionally, its role in the delivery of TA proteins to the ER is crucial for proper cellular function and protein targeting .
Research on the arsA arsenite transporter ATP-binding homolog 1 has provided insights into the mechanisms of arsenic resistance and the broader field of metal ion transport . Understanding this protein’s function can lead to the development of strategies to combat arsenic toxicity and improve bioremediation efforts. Furthermore, the study of its role in TA protein delivery has implications for understanding protein targeting and insertion into the ER .
