ARMS2 Human
Age-related maculopathy susceptibility protein 2, ARMD8
Greater than 85.0% as determined by SDS-PAGE.
Description
ARMS2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-107a.a.) and having a molecular mass of 13.8kDa.
ARMS2 is fused to a 23 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Age-Related Maculopathy Susceptibility 2 (ARMS2) is a protein currently being studied for its potential role in age-related diseases. Mutations in the ARMS2 gene have been linked to age-related macular degeneration.
Recombinant human ARMS2 protein, expressed in E. coli, is a non-glycosylated polypeptide chain consisting of 130 amino acids (residues 1-107). It has a molecular weight of 13.8 kDa. The protein is purified using proprietary chromatographic techniques and includes a 23 amino acid His tag at the N-terminus.
ARMS2 protein solution at a concentration of 0.25 mg/ml in 20 mM Tris-HCl buffer (pH 8.0), with 0.4M urea and 10% glycerol.
For short-term storage (up to 4 weeks), store at 4°C. For extended periods, store frozen at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity greater than 85.0% as determined by SDS-PAGE analysis.
Age-related maculopathy susceptibility protein 2, ARMD8
MGSSHHHHHH SSGLVPRGSH MGSMLRLYPG PMVTEAEGKG GPEMASLSSS VVPVSFISTL RESVLDPGVG GEGASDKQRS KLSLSHSMIP AAKIHTELCL PAFFSPAGTQ RRFQQPQHHL TLSIIHTAAR
Product Science Overview
Age-related macular degeneration (AMD) is a leading cause of irreversible central vision loss in aging populations worldwide . AMD is a complex, multifactorial disease influenced by both genetic and environmental factors . Among the genetic factors, the Age-Related Maculopathy Susceptibility 2 (ARMS2) gene has been identified as a significant contributor to AMD risk .
ARMS2 is located on chromosome 10q26, a region strongly associated with AMD . This locus also includes the HTRA1 gene, and both genes are in strong linkage disequilibrium, making it challenging to distinguish their individual contributions to AMD . Variations in ARMS2, particularly the rs10490924 polymorphism, have shown a strong association with AMD . This polymorphism encodes a protein that binds to the cell surface and enhances complement activation, which is crucial in the pathogenesis of AMD .
The ARMS2 protein is evolutionarily recent and specific to primates . It is involved in the regulation of the complement system, which plays a critical role in immune responses and inflammation . Dysregulation of the complement system can lead to significant damage to macular cells, contributing to their atrophy and degeneration .
ARMS2 is primarily expressed in the retinal pigment epithelium (RPE) and choroid, tissues that are critically involved in the maintenance of retinal health . The RPE is responsible for supporting photoreceptors and maintaining the blood-retina barrier, while the choroid provides oxygen and nutrients to the outer retina .
Understanding the role of ARMS2 in AMD has significant clinical implications. Genetic testing for ARMS2 polymorphisms can help identify individuals at higher risk for AMD, allowing for early intervention and personalized treatment strategies . Additionally, targeting the complement system and ARMS2-related pathways may offer new therapeutic approaches for AMD .
