ARMC10 Human
Description
ARMC10 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The armadillo repeat is a protein motif involved in protein-protein interactions. ARMC10 contains multiple armadillo repeats, which facilitate its role in various cellular processes. The protein also has a transmembrane domain, indicating its association with cellular membranes .
ARMC10 is known to interact directly with the DNA-binding domain of the tumor suppressor protein p53, leading to a decrease in p53’s transcriptional activity. This interaction suggests that ARMC10 may play a role in cell growth and survival by modulating p53 activity .
The primary biological function of ARMC10 is to regulate cell growth and survival. By interacting with p53, ARMC10 can influence the transcriptional activity of genes involved in cell cycle regulation and apoptosis. This regulatory mechanism is crucial for maintaining cellular homeostasis and preventing uncontrolled cell proliferation .
The expression of ARMC10 is regulated at both the transcriptional and post-transcriptional levels. Alternative splicing of the ARMC10 gene results in multiple isoforms, each potentially having distinct functions and regulatory mechanisms. Additionally, a pseudogene of ARMC10 is located on the long arm of chromosome 3, which may play a role in its regulation .
Given its role in modulating p53 activity and its upregulation in hepatocellular carcinoma, ARMC10 is a potential target for cancer therapy. Understanding the regulatory mechanisms and interactions of ARMC10 could lead to the development of novel therapeutic strategies for liver cancer and other malignancies .
