ARG2 Antibody
Description
Product Specs
Product Science Overview
Arginase Type II, also known as arginase 2 or ARG2, is an enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea. This enzyme is one of the two isoforms of arginase found in mammals, with the other being arginase type I. Arginase type II is primarily located in the mitochondria and is expressed in extra-hepatic tissues, especially the kidney .
Arginase type II is encoded by the ARG2 gene. Unlike arginase type I, which is predominantly found in the liver, arginase type II is distributed in various tissues, including the kidney, brain, and prostate . The enzyme plays a crucial role in the urea cycle, which is essential for the detoxification of ammonia in the body. Additionally, arginase type II is involved in the regulation of nitric oxide and polyamine metabolism .
The physiological role of arginase type II is not as well understood as that of arginase type I. However, it is believed to be involved in several important biological processes. For instance, arginase type II has been shown to promote macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis . It is also implicated in the regulation of immune responses and cellular senescence .
Mouse anti human arginase type II antibodies are monoclonal antibodies developed to specifically target and bind to human arginase type II. These antibodies are widely used in various scientific applications, including Western blotting, immunohistochemistry, immunocytochemistry, enzyme-linked immunosorbent assay (ELISA), and flow cytometry . They are valuable tools for researchers studying the expression, localization, and function of arginase type II in different tissues and under various physiological and pathological conditions.
The use of mouse anti human arginase type II antibodies has facilitated numerous studies aimed at understanding the role of arginase type II in health and disease. For example, research has shown that silencing arginase type II in human monocytes decreases their adhesion to endothelial cells and reduces the production of proinflammatory mediators . Additionally, studies using arginase type II-deficient mice have demonstrated the enzyme’s involvement in macrophage inflammation, glucose metabolism, and atherosclerosis .
