AMH Human, HEK
Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS, MIF.
Filtered White lyophilized (freeze-dried) powder.
Greater than 85.0% as determined by SDS-PAGE.
Description
AMH Human Recombinant is a single, glycosylated polypeptide chain containing 439 amino acids (19-451a.a) and having a molecular mass of 46.5kDa (calculated). AMH is fused to a 6 a.a His tag at C-terminal.
Product Specs
This section provides a brief overview of Anti-Mullerian Hormone (AMH), highlighting its alternative name, family membership, function, and roles in various biological processes.
This section describes the recombinant human AMH protein, specifying its structure, composition, molecular weight, and the presence of a His tag for purification purposes.
This describes the physical appearance of the AMH protein product, indicating it is supplied as a white powder that has undergone lyophilization.
This part details the formulation of the lyophilized AMH protein, indicating it is prepared in a solution containing PBS and trehalose to ensure stability.
This section provides instructions on how to reconstitute the lyophilized AMH protein, recommending the use of deionized water and suggesting a working stock concentration.
This part outlines the recommended storage conditions for the lyophilized and reconstituted AMH protein, advising storage at -20°C and 4°C respectively, and emphasizing the need to minimize freeze-thaw cycles.
This section states the purity level of the AMH protein, confirmed through SDS-PAGE analysis, indicating that it is greater than 85% pure.
Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS, MIF.
LLGTEALRAE EPAVGTSGLI FREDLDWPPG SPQEPLCLVA LGGDSNGSSS PLRVVGALSA YEQAFLGAVQ RARWGPRDLA TFGVCNTGDR QAALPSLRRL GAWLRDPGGQ RLVVLHLEEV TWEPTPSLRF QEPPPGGAGP PELALLVLYP GPGPEVTVTR AGLPGAQSLC PSRDTRYLVL AVDRPAGAWR GSGLALTLQP RGEDSRLSTA RLQALLFGDD HRCFTRMTPA LLLLPRSEPA PLPAHGQLDT VPFPPPRPSA ELEESPPSAD PFLETLTRLV RALRVPPARA SAPRLALDPD ALAGFPQGLV NLSDPAALER LLDGEEPLLL LLRPTAATTG DPAPLHDPTS APWATALARR VAAELQAAAA ELRSLPGLPP ATAPLLARLL ALCPGGPGGL GDPLRALLLL KALQGLRVEW RGRDPRGPGR AQRHHHHHH
Product Science Overview
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Sexual Differentiation:
- During male embryonic development, AMH is secreted by the Sertoli cells of the testes. It causes the regression of the Mullerian ducts, which are precursors to female reproductive organs such as the uterus, fallopian tubes, and the upper part of the vagina .
- In the absence of AMH, as in female embryos, the Mullerian ducts develop into female reproductive organs .
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Reproductive Function:
- In females, AMH is produced by the granulosa cells of the ovarian follicles. It plays a role in regulating the growth and development of ovarian follicles by inhibiting the recruitment of primordial follicles and decreasing their sensitivity to follicle-stimulating hormone (FSH) .
- AMH levels in the blood are used as a marker of ovarian reserve, which reflects the remaining quantity and quality of a woman’s eggs. This is particularly useful in assessing fertility and predicting the success of in-vitro fertilization (IVF) .
Human Recombinant AMH (HEK) is produced using Human Embryonic Kidney (HEK) cells. This recombinant form is used in various research and clinical applications due to its high purity and biological activity .
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Production:
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Applications:
- Clinical Diagnostics: Recombinant AMH is used in immunoassays to measure AMH levels in serum or plasma, aiding in the assessment of ovarian reserve and fertility .
- Research: It is used in studies investigating the role of AMH in reproductive biology, cancer research, and other areas of endocrinology .
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Fertility Assessment:
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Cancer Research:
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Endocrinology:
