Angiostatin K1-4
Description
The Ang K1-4 is purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
Angiostatin was first discovered in the urine of tumor-bearing mice and was later characterized as an internal fragment of plasminogen, a precursor protein involved in the breakdown of blood clots . The angiostatin molecule is composed of the first four kringle domains of plasminogen, hence the name Angiostatin Kringles 1-4 .
Angiostatin exerts its anti-angiogenic effects by inhibiting endothelial cell proliferation, migration, and tube formation, which are essential steps in the angiogenesis process . It achieves this by binding to specific receptors on the surface of endothelial cells, thereby blocking the signaling pathways that promote angiogenesis .
The biological activity of angiostatin has been extensively studied. It has been shown to inhibit the growth of various tumors by preventing the formation of new blood vessels that supply nutrients and oxygen to the tumor cells . Additionally, angiostatin has anti-inflammatory properties, as it can inhibit the interaction between leukocytes and endothelial cells, thereby reducing inflammation .
Given its potent anti-angiogenic and anti-inflammatory properties, angiostatin has been explored as a therapeutic agent for treating cancer and other diseases characterized by excessive angiogenesis and inflammation . For instance, in a humanized-plasminogen mouse model, the administration of angiostatin significantly inhibited tumor growth .
