ALDOA Antibody

Aldolase A, also known as fructose-bisphosphate aldolase, is a crucial enzyme in the glycolytic pathway. It catalyzes the reversible conversion of fructose-1,6-bisphosphate into glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) . This enzyme is encoded by the ALDOA gene in humans and plays a significant role in energy production within cells.

Aldolase A is a key enzyme in the fourth step of glycolysis and is also involved in gluconeogenesis . It is a member of the class I fructose-bisphosphate aldolase protein family and is expressed in various tissues, including muscle, liver, and brain . The enzyme’s activity is essential for maintaining cellular energy levels, especially in tissues with high energy demands.

The analysis of aldolase levels in the blood is used to assess muscle and liver function . Elevated aldolase levels may indicate muscle or liver damage, inflammation, or certain autoimmune diseases . Conversely, lower-than-normal levels might suggest a deficiency in aldolase production. This enzyme is also associated with Glycogen Storage Disease XII, an autosomal recessive disorder characterized by hemolytic anemia .

Mouse anti-human Aldolase-A antibodies are monoclonal antibodies developed to target and bind specifically to the human Aldolase-A protein. These antibodies are used in various scientific applications, including Western Blot, Immunocytochemistry, ELISA, Immunohistochemistry, and Immunoprecipitation . They are valuable tools for studying the expression and function of Aldolase-A in different biological contexts.

Mouse anti-human Aldolase-A antibodies have been used extensively in research to investigate the role of Aldolase-A in various diseases, including cancer and metabolic disorders . These antibodies help in identifying the presence and quantity of Aldolase-A in tissue samples, aiding in the understanding of its involvement in disease mechanisms.