AK3L1 Antibody

Adenylate Kinase-3 Like 1 (AK3L1) is a protein that plays a crucial role in cellular energy homeostasis. It belongs to the adenylate kinase family, which is responsible for catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This process is vital for maintaining the balance of cellular energy levels.

Adenylate kinases are small, usually monomeric enzymes found in all living organisms due to their essential role in energetic metabolism . The primary reaction catalyzed by adenylate kinases is:

$$\text{ATP} + \text{AMP} \leftrightarrow 2\text{ADP}$$

This reaction is critical for the regulation of cellular energy levels.

AK3L1, specifically, is one of the isoforms of adenylate kinase. It is known to regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate groups among these nucleotides . Unlike other adenylate kinases that primarily use ATP, AK3L1 can also utilize GTP (GTP: AMP phosphotransferase; EC 2.7.4.10) .

The gene encoding AK3L1 is located on human chromosome 1 . Mutations or dysregulation of this gene can lead to various medical conditions. For instance, the impairment of mitochondrial isoenzymes, including AK3L1, has been demonstrated in neuroblastoma or glioma .

Adenylate kinases, including AK3L1, are integrated into the global network of energetic processes in any organism. They are valid targets for new pharmaceutical compounds due to their role in maintaining cellular energy balance . Dysregulation or mutation of adenylate kinases can be associated with several diseases, including metabolic syndrome and neurodegenerative diseases .

The Mouse Anti Human AK3L1 antibody is a monoclonal antibody used in various research applications. It is designed to specifically bind to the human AK3L1 protein, allowing researchers to study its expression and function in different biological contexts . This antibody is particularly useful in disease detection, drug monitoring, and various other biomedical research fields .