AGXT Antibody

Serine-pyruvate aminotransferase, also known as serine-pyruvate transaminase, is an enzyme that plays a crucial role in amino acid metabolism. This enzyme catalyzes the reversible transamination reaction between L-serine and pyruvate to produce 3-hydroxypyruvate and L-alanine . The mouse anti-human serine-pyruvate aminotransferase antibody is used in various research applications to study the enzyme’s function and its role in different biological processes.

Serine-pyruvate aminotransferase belongs to the class of transferases, specifically aminotransferases, which transfer amino groups from one molecule to another. The enzyme’s systematic name is L-serine:pyruvate aminotransferase, and it is classified under the EC number 2.6.1.51 . The reaction it catalyzes is essential for the metabolism of serine and glycine, two important amino acids involved in various cellular functions.

The enzyme’s activity involves the transfer of an amino group from L-serine to pyruvate, resulting in the formation of 3-hydroxypyruvate and L-alanine. This reaction is part of the serine and glycine biosynthesis pathway, which is critical for cellular growth and proliferation .

Serine-pyruvate aminotransferase is found in various tissues, including the liver, kidney, and brain. It plays a significant role in maintaining amino acid balance and supporting metabolic processes. The enzyme’s activity is regulated by various factors, including the availability of substrates and cofactors such as pyridoxal 5’-phosphate .

In addition to its metabolic functions, serine-pyruvate aminotransferase has been implicated in several physiological and pathological processes. For example, alterations in its activity have been associated with metabolic disorders and diseases such as primary hyperoxaluria, a condition characterized by the overproduction of oxalate .

The mouse anti-human serine-pyruvate aminotransferase antibody is a valuable tool in research. It is used to study the enzyme’s expression, localization, and function in various biological systems. Researchers utilize this antibody in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to investigate the enzyme’s role in health and disease.

By using this antibody, scientists can gain insights into the enzyme’s involvement in metabolic pathways and its potential as a therapeutic target. For instance, understanding how serine-pyruvate aminotransferase contributes to amino acid metabolism can help develop strategies to treat metabolic disorders and other related conditions .